Disease Name: Biotidinase Deficiency
>sp|P43251|BTD_HUMAN Biotinidase OS=Homo sapiens OX=9606 GN=BTD PE=1 SV=2
MAHAHIQGGRRAKSRFVVCIMSGARSKLALFLCGCYVVALGAHTGEESVADHHEAEYYVA
AVYEHPSILSLNPLALISRQEALELMNQNLDIYEQQVMTAAQKDVQIIVFPEDGIHGFNF
TRTSIYPFLDFMPSPQVVRWNPCLEPHRFNDTEVLQRLSCMAIRGDMFLVANLGTKEPCH
SSDPRCPKDGRYQFNTNVVFSNNGTLVDRYRKHNLYFEAAFDVPLKVDLITFDTPFAGRF
GIFTCFDILFFDPAIRVLRDYKVKHVVYPTAWMNQLPLLAAIEIQKAFAVAFGINVLAAN
VHHPVLGMTGSGIHTPLESFWYHDMENPKSHLIIAQVAKNPVGLIGAENATGETDPSHSK
FLKILSGDPYCEKDAQEVHCDEATKWNVNAPPTFHSEMMYDNFTLVPVWGKEGYLHVCSN
GLCCYLLYERPTLSKELYALGVFDGLHTVHGTYYIQVCALVRCGGLGFDTCGQEITEATG
IFEFHLWGNFSTSYIFPLFLTSGMTLEVPDQLGWENDHYFLRKSRLSSGLVTAALYGRLY
ERD
>NC_000003.11:15642848-15687329 Homo sapiens chromosome 3, GRCh37.p13 Primary Assembly
AGCTTCCGTAGGAGCCTTTCATTCCAGGAAGGTCCATCGTACTTGCGTTTTCAGGGCCTGAGCGATGACT
TTAGCACCAGACACCTGCTCCTCGCTGCGCTCTGCGAAGTTACTGTCCGGCATCTTCCACCGAAAAGCTC
TAAGCACTCACGCAGCCGGCAAACAAGCGGAATCATCCAGCAAGGCAAACGCGAAATCGGCAGCACGCCA
CCTCTGGTACTGCACCTCTGACGGACAGGAGGGCAACCAACTGCCTTAAACAACGGGAAGGAAGAGGCGG
TCTAAATTCGTCCACTTCCCGGGAGAGGTGAGAATGTAAACACGCGCGTTCTCCAATCAGAACTGCGCTC
TCTTCTCGGCTCCTCCATTCGCGCGCCAGAATGCCAGAGGGAGGCGGGACTAGCAGGAGATTGCTGCCTA
TGCAAAGCAGGTAAGAAGCCGAACTCTGAGGCCTCTCGCCATTGTCTCCGAGTCGGCCAGCTGGAGCGTT
TTCGGGGCTGTAAAGGGAGAATGGCGCATGCGCATATTCAGGGCGGAAGGCGCGCTAAGAGCAGGTACGG
AGGGGGCGTGGTGCGGCGCGGAGGGGGTGTGGTAAGGGCGTGCGGTCCAGACCCCGCCCCGGGCGCCCAG
TTGGACTTGGGGAGGGCTGCGCAAAGGCTGCCGGGAGCTGGGAAGCCCGGCGCGCGTCGTTTGCTGGGGC
TGTTTGTGCGTTGCTGCTGTGCTACCGCGTTGCGTTTTCTAGGCATTTACTTACACGCTTTGTGGTTTAC
GCTCTCATAACCTTGTGGTTTTATAGTCCTTAAATTATTGTAGCGCACGTTACTTAAATCCAGAAGCAGA
TGTGTACCCCAGCAAGAGATAAAATGACGCTCAGAGTCAGTAGATCCAGACCGTGCCTGAGATCCTGAAT
CCTGTTTCCTACCCACTATTCAGCCATTGGGTCACAAGCGATGAAAAGAGCACCTTGAAGGTAGTATAGA
GCACTGTTTTCTCCAGCCCTTGCTACTAATCCATATTACTCTCCGCTAATATCTTTCCAAAATTAGGAAC
TATGGCGTTTCATAATTCTTAGGTTGGGTCCCTACCTACAACCAGCCCTGCACCCGATAGCCTTTTAAAA
CATTTTTGTGTGAAAATCGTTTGCAATGTGCAATATCTGAAACTACTGCCTTGGAGTCATTAGACCCTCT
GCTCAGTGACAATAAACATAAAATTTCCAATTGTAATAAACAGTGGAACTTTTAATTTTTTGAGGATTTG
GAGTCATTTTAAGCAAAAAGAACAGTGATAAGTGGACAGTAAAGAGATGAGAGGGGAGTGGGTCATGGGT
AGTGAAATGAGTGAGAAGCACTGGAAGTGAAACGATTTCTAAACCCAGACATTTTCAAACTGTAGTCCTG
GGTCTTTTCAAAAGGTCTTCCCCTCTTTTTCTCAACCCCTCAACCCCACCCCAAGCAGAGGAGAGTGAAG
TGGTTGCCTCCCTGCATATGTGGACGGTGTTAGTCCATTTTCATACTGCTATAAAGAAATACCCAAAACT
GGGTAATTTATAAAGAAAAAGAGGTTTAATGGTCTCACAGTTCCAAATGGCTACGGAGGCCTCACAATCA
TGGCAGAAGGTGAAGGAGGAGCAAAGGCATGTCTTACATGGTGGCAGGCAAGAGAGCGTGTGCAGGGGAA
CTGCCCTTTATAAAACCATCAGATCTCATGAGACTTACTATCATTAGAACAGCATGGGAAAAATCCCCTC
CCCATGATTCAGTTACTTCCCACTGGGTCCCTCTCACCACATGTGGGGATTATGGGAGCTATAATTCAAG
ATGAGATTTGGATGAGGACACAGCCAAACTGTTCTGCCCCTGGCCCCTCCCAAATATCATATCCTCACAT
TTCAAAACCAATCATGCCTTCCCAACAGTCCCCCAAAGTCTTAACTCATTTCAGCATTAACTCGAAAGTC
CACAGTCCAGAGTTTCATCTGAGACAAGGCAAGTCCCTTCCGCCTATGAGCCTGTAAAATCAAAAGCAAG
CTAGTGGCTGGGCGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATCATG
AGGTCAAGAGATGGAGACCATCCTGGTCAACACGGTGAAACCCTATCTCTACTAAAAATACAAAAAATTA
GGCGGGCATGGTGGCAGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATGGTGTGAACC
CGGGAGGCAGAGCTTGCAGTGAGCTGAGATTGGGCCACTGCACTCCAGCCTGGGGGACAGATCGAGACTC
CGTCTCAAAAAAAATAATAAAATTAAATTTAAAAATAAATAAATAAAAGCAAGATAGTTACTTCCTAGAT
ACAATGGGTGCACGGGAGTGAGGTAAATATACCCGTTCCAAATGGGAGAAATTGGTCAAGACAAAGGGGC
TAAAGCCCCCATGCAAGTTCAAAATCTGGCAGGGCAGTCAAATATTAAAGCTCCAAAATGATCTTTGGAT
CATTTTGACTTCGTATCTCACAGCCAGATCATGCTGATGCAAGAGGTGGGCTCCCACAGCCTTGGGCAGC
TCTGCCCTTGTGGTTTTACAGGCTACAACCCCCTCTCCCAGCTGCTTTCACAGGCTAATATTGAGTGTGT
GCAGCTTTTCTAGGCACATGGTGCAAGTGGTCAGTAGATCTACCATTCTGGGGTCTGGAGGACGGTGGCC
CTCTTCTCACAGTTCCACCAGCAGTGCCCCAGGAGGGACTCTGTATGGGGGCTCCCACCCCACATTTCCC
TTCCACACTGCCCTAGCAGAGGTTCTCTATGAGGGCTCTACCCCTGCAACAAGCTTCTGCCTGGACATCC
AGGCATTTCCATACATCCTCTGAAATCTAGGCAGAGGTTCCCAAACCTCAATTTTTGACTTCTGTGCACC
TGCAGGCTCAACACCATGTGGAAGCTGCCAAGGCTTCAGGCTTGCACTGTCTGAAGCCAGGCCTGAGCTG
TACATTGGCCCTTTTTAGCCATGGCTGGCATGGCTGGGATGCAGGACACCAAGTCCCTAGGCTGCAAACA
GCAGGGGGACCCTGGACCTGACCCATGAAACCATTTTTCCTCCTAGGTTTCTGGGCCTGTGATGGGAGGG
CCTGTTGTGAAGGTCTCTGACATGCCCTGGAGACATTTTCCCCATTGTCTTGGTGATTAATAGTTAGCTT
CTTATTACCTATGCAAATTTCTGCTGCCAGCTTGAATTTCTCCCTAGAAAATGGGTTTTTATTTTCTACT
GCATCGTCAGTCTGCAGATTTTTCAAATTTGTATGCTCTGCTTCCTCTGGAACACTTTGCCATTTAGAAA
TTTCTTCTGCCAGATACCCTAAATCATCTCTCTCAAGTTCAAAGTTCCACAGATCTCTAGGACAGGGGCA
AAATGCCACTAGTCTCTTTGCATAGCAAGAGTGACCTTTACTCCAACTCTGAATAAGTTCCTCATCTCCA
TCAGAAACCACTTCAGCCTGAATTTTATTGTCCATATCACTATCAGCATTTTGGTCAAAGCCATTCAATA
AGTCTCTAGGAGGTTCCAAACTTTCCCACATTTTCCTGTCTTCTGAGCCCTCCAAGTCTCTAGGAAGTTC
CAGACTTTCCCACATTTTCCTATCTTCTTCTGAGCCCTCCAAACTGTTCCAACTTCTGCCAGTTACCCAG
TTCCAAAGTTATTTCCACAGTTTCGGCTGTCTTTACAGTAGTGCCCCACTCTCTGCATTACCAATTTTCT
GTGTTAGTCCCTTTTCATACTGCTATGAAGAAATACTCAAAACTGGGTAATTTATAAAGAAAAAGAGGTT
TAATAGATTCACAGTTCCACATGGCTGGAGAGACGTCACAATCATGGTGGAAGATGAAGGAGGAGCAAAG
GCACGTCTTACATGGCGACAGGCAAGAGAGTGTGTGCAGGGAAACTCCCATTTATAAAACCATCACAGCT
TGAGACTTATTTGCTATCACAAGAACAGCATGGGAAAAACCCTCCCCAATGATTCAGTTACCTCCCACCA
GGTACCGCTCATGATATGTAGGGATTATGGGAGCTATAATTCAAGATGAGATTTGAGTGGGGACATAACC
AAACCATATCAGGGACCCATCTCAGAGGGTGACTTCTTTCAAGTCTCAGAGTGTATCTAAAAAGAAAATG
CAGATTTTGTATTATACTCTAGAATGTATCCATATTTTAATTTTAAAATGACATTTATTGAGATATAATA
AAGATACAATTCAATGTCCAGATTTTAAATGTTAGATGAGTTTTGACAGTTATATATATATATATCTATG
AAATCACCACCCAAAATAAAAATGACATTTTAAACTGCTTACCTGTCAAGTAAAATTGACATTCCAGAAA
GATGTGAAACGGGCTGGGCACAATGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCAG
ATCATCTGAGGTCAGGAGTTCGAGGCCAGCCTGGCCAATGTGGTGAAACCCCATCTCTGCTAAAATACAA
AAATTATCCAGGTGTGGTGGCACATGCCTGTAATCCCAGCTATTCGGGAGACTGAGGTGGGAGAATCGTG
TGAGCCAGGGAGGTAGATGTTGCAGTAAACCAAGATTGCACCACTGTACTCTAGCCTGGGTGACAGAGCG
AGACCCTGTCTCAAAAAAAAAAAAAAAAAAAAAAAAGATGTGAAATCATCTTTGCACTTTGAGTAGTCCT
TGACACAATGCCTCCTGTCCTTGTTGAAGAAGTACAGACTTCCCCTTCCATCATGTATTATTTATATCAG
TACCTTTTGTGACAGTCTCTGCCCCTGTTGCATTAGAGTCACTTGGAAAGCTTTTTCCAAATAGTTACTT
GGGCCCTACCCCAGATCTCCTGAATCAGCATCTTAGGACAAGTCAGGCACCTGTATTTTTTAAAAGCTGC
TACCTGATTTTGCTTTGCAGCCCAGAGTTGAGAACCCTAGCTCTGTTTTCATGCCAGAAGCATGAGTTAC
TAATTAAACATATGATTGCCTGTCACCAAAGTAATACTGTTGATTAATTTGGATTGACAGGTTCAAGACT
GATTTGACATTGACAGAACAAGCTGTATCGATGGTAGTCAGTTCACTGGGCCTACTTCTGTGTCAAAAGA
AACAGTGACAGAACCACTCAGTATGAAGTGCAATGAAAACTGAACTCTGAATTGGAACAAATAACTGGAA
TTCAGTTAACTGGTTTTGCAAAAGGATAAATACTCAACTGGTTGTTTTCTGCCATTTAACAAAGAGAAAA
ATCATTGGGATTGTTTAAACTTGCTTTCACCTTTGCACCTTTCAGTTCAGGATGCAGTGTTCAATTGTTA
ACTTGGGCTTGATGATTCAGCAGAAAGAAATGATTTGAGTTCTGGCTCACTGGATTAACAGGGCCAAGGA
GCAAGTCCTTTGCAATCCAATTGTAATTACAGCCAGCTTGTCCAACCCTTGGCCCAGGATGGCTTTGAAT
GCGGCCCAACACAAATTCATAAACTTTCTTAAAACATTATGAGATTTATGCACCGACCCTTTTTTTTGTT
GTTGTTTTTGGTTTTTTTTTTTTTTTTTAGCTCATCAGCTATCATTTGTGTTAGTGTATTTTATGTATGG
CCCAAGACAATTCTTCTTTTTCCAGTGTGGCCCAGGGAAGCCAAAAGATTGGATACCCCTGACAGGATTC
CAGGATTCTTTTGTAATTTCTCAGAGGCCCTCTGTGCATACTCCGTAAGGACTATCCACATTCTTTATTA
CTTTCATTGGCAATAGGTATAAAATTTTATTTGTTGGATATTTTACTGAAATGTTACTTGTTTTTGCTTA
TTTACTGATTGGTGGGAGGAAGTCAAAGGATGAATAAATCTAACCTTTTTAAAAGAAAAGGCTAAAATAC
TCATAACATGCTCTCCAAAGAGCAGAGCTAGTCATCAAAGAATCTGCATACCAATTACTCTATTTGTAGG
TTCTGGATTTGAGATTATGAAAAAGAGCAAATTGGTGGTTTTCTTCTCTCTGGGCCAGGGAGATATCCAG
GCAACCAGGTAATTTAGTAAGAATTGCAAATATAGTGCCTGGAGACAATTTATTCTCTAAAGACTGCAGC
TTCTACAGGCAGTAACTCTTAAAGCCCCCAAATTGGGATAGTGCATTTTAATTTCCGTATACTAACAAGG
ACACTAAAAATCCTTGTGATTATTTTAAAGCATAACACTAGCTGAACTTGTGATTAAGTATTCTCACAAA
TGTATTATCAAAATGTGAAATGTTTACTTATCAAATGAGGAAATGAATCAAGGTCATTTGTGATACATTA
TAGAAGCTAAAAATGAAATTGCCTGACATAAGATAAAACTGATACTGAATATCTTAAAAATAAAAAGGCG
GAAACAACAAAAAAAGGAGTCTATGTAGAACACTATTTTTTATAGCAATGCAAAAACTGTACAGCCGGAA
ATGTGTTGTAGGAAATATGTCAACATAGGAAGTAAAATAATGTAATGAAAAGGTTCTTTGAATAAAGTGG
GTTAAATTGATTTTCTTTGCTTCTCATTAAATCTGTGGACTTCAGAGTACCAAAGCTCAGCAACAGGCTT
GAAACAAACCCAGTGAAAAGCAACTTTATTATTGAGCTGAGGATTGATATCAGTAATAACTCATTAATAA
AAAAGCTTGATAATAAAAACTCCCAGTGCCTGATGCCAGCTGACAGACACTGGGAGTTTTCCCAGGTACC
CTGTGACCTAGAGAAAGCTTGGATTCCTGCCTTTGGCTTGGGCTGGCAAGCCCTGTGCCTTTACTCTACA
TTTTAATGCCAGGGAGACCTGGAACTGGAGAAGGGAGTGCTGTGGGAAGAAAACAGAAGGAATGTTGTTC
CCTTGTTTTAGCTTTGTGTTCATCCATTATGGGTTTTGGGTTTTTTTGTTTTTTGTGTTTTTTTAAGAAC
ATTTGAGATAGTTTGACAGCAGCAGTCATTACATCACTGACGAGGACGTTTACTTGTGTAAAATGCACCA
GGAAATAGTGACAACTGTATGTTGTGCTATGAGGATGTAAGAGATTTATCTCAAATGGCTTAGAAATCAA
AATATAGGTCAGTGCGGTGGCTCACACCTGTAATCCCAACACTTTGGGAGGCCAAGGCAGGCGGATCACG
AGGTCAGTAGATTGACACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAG
CTGGGCATGGTGATGTGCGCCTGTAATCCCAGCTACCGGGGAGGCTGAGGCAGGAGAACCACTTGAACCC
AGGAGTTGGAGGTTGCAGTGAGCCGAGATTGCGCCCCTGCACTCCAGCCTGGCGACAGAGCGAGACTCCG
TCTCAAAAAAAAAAAAAAAAAGAAATCATAGTATTTCTCCGTATGATGGAATTCCATACTCGGGGGAGTG
TCCCACAGGGTAGGCAAGCAGCTATCACCCATGTAATATGGTACTAGTGTTGAAATATTTTCTGTTTTCA
CTTGCTTCTTCTGCCATTAGCATTCATTACAGCCCTTTCCTTTAACTTTTTAATTTGTACTTTATTGCTT
TGTTTTGATAATAATCTATTCTCCATGTCAGCAAAACAAAGATTTATCTCTAGGGAAGAATCTCTGAGTG
ATTCCCAGGGTTTGGGGGTTGAACTGGGGACATCTTCATGATGAACTTAAGCCCTTAAACTTCTTTTTAC
ATCATAACGTTTGAGTTCTTCTTTGGAGCTTAGCTGTGATTTATTCTTTTCACTTCAAAAAAAATACATT
TAACATTTATGACATCTTTCAGACACATGAATAGGATCAGAGATTAATATACACCCATGTACCCAGCCCC
TGGCTTAAGAAATACATCACAAATATAATGAAACCCCCGTGTGTCCTTTCCCCATTACACCTCCTTTCCT
GTCCTACAGAGGTAACCACTATCTTGAATTTGGTGTTTGTAGTTCCCACATTATCCATTCTTTAGATGAT
CGATATTTGGTCATTTTTAGTTTTTTTGGAAACAGTGTGCTCTGAAATTCTTGCATGTTTCCTTCTTGTG
CACATGTGTGAGAGTTTCTACATATATATCAAGGTGGAGGTCATCATCATTTGATCTCCAAAGTATTGTA
CCAATTTATACTCCCAACATTTGTGTATGAGAGCTACCCTTTCTCCATAGTCTCAACTGTGGAGCTTTAA
AAATTTTTAAATGTGAAATGGCTTCTCAGTTCCATTTCTCTGACTACAAATGAGGTTAAGTTATATTTGT
ATATATATATTGGCCATGCGTGTTTCTTTTTCTGTGAATTACGTGTTTACATCTGTTGCACATTTCCTTA
TTGGATTATCTTTTGCTTTTTGATTTGTAGATGTCCTTTATGTATTCTGAATGCTAATTATTTGTCTTTT
AACTTTGTTAATAGTGATTTTAGAGGTATAAAGGGTTTTTTTATAGTCACATTTGACAACTGGTCTTCCT
TATTTTTTTTTTAATTTTTTTATTTTTTTGGTAACTTGCTAAAGAAAACTTTTTGTAACCTGAGGTTATG
AAGATTTTTTTCTATATCAAAAAGTGTAAAGTTTTATTTTTCATATTTAAGTCACTACCTGGAATTGATT
TTTGTTTGTTGAGAAGTAAGAATCCATATAATATGTCAATTAGATTTGCTGTGTAATTAACCACCCCAAA
ACTTAGTGGCTTAAAAGAACCACCATTTATTTAACATATATTCCTATGAGGCTGGTCTCAACTGGGCTCA
CCCATGTATCTGTTAGTCAGTTGCCAGTGAACTGAGTCACTCAGCCCCTGGAGGTTAGCTGGTTGTCCAC
TGGGATAGCGGGCATATTGCCAGTGAGCCACATAGCTCTACCACTCAGCAGGCTAGCTGGACTTCTTCAT
TGGATGGCAGCAGGTTGCAAAAGGGAATGAGCCTCATTGTGCAAGCCTCTATGTGCGGTGTTTGCTAACA
TCTCATTAGCCAAAGCAAGTTATGTGGCTGGGCTCAGACTCTAAGTTAAAGGCATTCGAGTTACATGATA
ATGGAACATGGATACAGAGAGGGGAGAAATTGCTGGCCTTTTTTATAGTCAATTTACCATAACATCCAGT
TGTCCAAGCACCATTCATAATATAGTTCATTCTCATCCCAGTGATACATAATTTCCCCTCTGTGGAATGT
CAAGCTCGCATATTTATGGGAGTATTTCTGTACTCTCTGTTCTTTTCCTATCCTAACACCAATCCCACAC
TATCTTAATTTCTGTGTTTTTAAAATAAGTCTTGATGTTGGTAGGACAAGTAGTCCCTGGACTTCATTCT
TTTGAAGCCATCTTGTTTATTATATTAATTTTAAGCAACTAGAGGGGATGGAAGAGGAACCTTTAGATTA
AAAGAGATTTAAAAGATAGGGTATTTTTTAATGGACAAGACTAAACTACAGTGTCTAGGGATGCACATTG
GGTGATAAAGCTATTTTAAAAAACAAAGAAGTGATGAGTATAAAAGTCAGGGTCATGGTTACTTGATCCC
TCATGGGTAATGTTGTCAGATTTAGAAAAAAAAAAAAAAACAGGACTCCAAAACTCCCAGTTGAATTTGA
ACTTTAGATGAACAATGCATAATTTTTTTTAGCGTAAGTATGTTCCAACATATTTATCTGAAAGTTAAAT
TTAACTGGGCCACCTGTATTTTACCTGGAAAAATCCTGATTTTATTCAAGGTGATAATGCAGTTTACATT
GCCCAGCCTTCCTTGTAGCTAGGAGTGGTCACGCGTCCACACATGGGCCAAAGCAATTTAAATAGGAGTC
ACTGGGCAGGGCTTTTAGGAAAGCTGATGAAACTGGCAAGTACCCTCTGTACTCTTCCTCTGTACAACAT
GATAATTGGAGTTGTAGAAGTCATTTTGGAACCACAAGATGACTCTGAAAATGGAAGCTACATGCCAAGA
AGTTAGGCCCAGAAAGAGAGGGATCCTGGGTCCTACATGACTCTTGCCTTTGTCAGGTTTTATTATCAGA
TTTTTATCACTTCATAAGAAAAAAATGCCTTCTTTTACTATATTCTCACACACATTGAGTAGCATTAGGA
TTATTTTTTCCTTTATAGTTAGAAAGAATTCTTCTAGAAACTATTTGGGCCTGTTTTGAGGGTGGAGAAT
GGGAGGGAATGATTGTTTGATAACTATTTCTTCTATGATTGTTGGCATGGTTTAGTTTTTTCTTTTATCC
GAAGTTTTGGTAAAAATATATTTTTCAGTCCCAGCTACTCTGGAGGCTGAGGCACAAGGATTGCTTGAAT
CCAGGAGGCAGAGGTTGCAATGAGCTGAGATTGCACCACTGCACTCCAACCTGGGTGATGGCGTGAGACA
GTCTCAAAAAAAAAAAAGAAAAAACAAATAATGTATTTTTTTTCTAGGAAACTACTCGTCTAAATTTTCT
AGCTTATCAATATAGGATTGAATGAGGTGATTATTCTTTTTTAAAAAAAATTCTTCTGCATTTATAGATT
TCTCTTTGTTTTGTATATTTGTTTCTCTTTTTTTTCTTAATTAGGCTAGCCGATCATTTGTCTTTACCTT
TTTTTTTCTCTAAACAACAACTCCTTGGACATACTTATTCATTCTGTCATTTTTCTGTTTTCTAATTTAA
TTTCCACTCTTATTTTTATTTCCTTCCTTTTGCTTTCTTGAGCATGCCATTACTCTTTTCCTCACTGTTA
CCACCTTTTGTTAGTTTTACAATTTCTACATTGCCAGAGTTAATAACATTTGCACTGTGTTCTATAAATA
TAATCCTCATGTTTATTTTACATTCAAGGCTCTTGCCAGTTTTTCCATTCACCTCTTAATTGGCCGAAGA
TTACCCTCTATGCATTTTTTCAAAGAAGGCTGATGAGACTGATGAGAATAATAGTCCCTGAGTTCTTATA
TTTTCATACCTATTATCTGGTTTTTTTCTTTACTTCAACCATAGGTTGGCATAATATATAATTTCTGGCT
TATATTTTATTTTCTGGAAGGATTCTATAGGCTTTTACTGGCATTGATGTTATTGTAGTAAAGTCTGAGG
ACAGCCTGATTATTTTGCCCCTAATAAATACCCTTGATCTTTTTATTTAGCTTCCCAAATGATTCTTACT
TTATCTTTGAAGATCAAGAATTTTGCTAGGCTATCTGCCGATGTTGATGTTCTGTTCCTTTCTTTCTTGA
GTTTTGCTATCTCTTTTCAAGCTATAAATTGAAATATGCTTTTATTTCTGGTGAGTTTTCTTCAATTACA
TCTTTAATTTTTTTTTTTTTTGCTTCATTATATGTTGTCTATTGTTGTATAAAAATTTACCCTACGACCT
ATTCAGCAGCTTAAAACAAGACCCATTTATTATCTCAAAGTCTCTATGTGTCAGGAGTCTGAGCATAGTT
TTACTGGATCCTCTGGTCAGCATCTCACAAGGCTACAGTGAAGTTGTCAGCTGACCTCATGGTCTCATCT
GAGGCTGAGTTTTCTTCCAAATTCAACTGATCGTTGAAAGAATGAATTTCCTTGCAGTTGTAGTATTCAT
GGTGGCTTGCTTCTTCAAGGTCAGCCGGGGAGAGAGTGTGTCTGAAATCTTGGAGCACCCCAGTTCTTTT
TTTAAAGACCTGATTAATTCAGACCCACCAGGGTAATCTCTTTTGATTAACTAGATTAACTGGCTTGGGA
TTTTAACTACATATGTGAAAGCCCTTCACCTTTGTCATATTCTATTGGCTAGTAACAGAGTACAATTTCC
ACCTGCACTCAAGAAAAGAGGATTATACAAGGAGTCACCTTAGGGTGTGTCCACCACACATTATTTTTTT
CTTTTATGCATTTTCCAATTATGCATATGATGGATCTCGTTCACTGTTCTCCCTGTCTATCATTTTCTGT
GGACTCCTTTTCAATTCTGTATTTCCATTCATGTTGCTTATTTATTTACAGCATCATCTGATTTCTTTTG
CTGCTTCTATCTTTGCCATAATTTCTTGATGTTTTAATTTTTTCTTCTGCTTCTTTCCTGAGCCCTGCCA
GATAATATTTCATCTGTCTCCCAGCTTTCTATTCCCCACTCCCTTCTCCCTTCTCTCTTCTTCCCTCTTC
CCCCTCCTTACCTTCTCCTCTTCTCCTCCTTTCCTCCCCTTCTCCCCTTTTTCCCTTTCATCTTTTAATT
CTCTTGGTCTATTTTGTGCTTTTATTTAATATAAGCAGTTTTTTTTCACTCGTGGCAGAATGTTTTGTCA
CAGTTTTTATTTGTGTTGTGGCAATTTTCTGGGGTATAACCTTTGTTTTCGTATAGTATCTTTCAAAAGA
TCTTGAGCTTTTTATTTACTCATTTTTGAGTGAGTTTTTCCTCTACTGTAGGAGGTTTATGTGTGAACAA
GGCCATTCTGGTTCACAGTTATTTTTTCTTAGCACATTTAAGATTTTGTTTTCTTACTTCTATTGTTACT
CTTGAAAAGTCTGCTGTTTTCAAATCACCATATCTTTGAAGGCAATCTCTCTTCCCTCTGGTTGCGTCTA
AGATTTTTTTCTTCTTCAAATATTTCGTGTTCTGGTTTCTTTATGTTGTGTATAGATTTCTTTTTGGTTG
TCTTGAATCTATGGATTTCTGTATTTTATTATTAAAATTCTCACCTATTATACCTTCAAACATGTGTAAT
GTGTCATGTGTCATTTTATGTATTTTCTCCCTCTTTCTTTCTTTCTTTTTTTTTTTTTTTTAAGTCAAGG
TCTTGCTCTGTCGCCCAAGCTGGAGTACAGTGGCACAGCCGTAGCCCACTGCAGCCTTAAACTCCTGGGC
TCAAGCAATCCTACCACCTCAGCCTCTTGAGATGCTGGGACCGCAGGTGTACACCACCATGCCCAGCTAA
TACTTTTTTACTTTTTGTAGAGATTATATTGCCCAGGCTGGTCTTGAATTCCTGGCCTCAAGTGATCCTC
TCATCTTGACCTCCAAAGTGTTGGGATTACAGGCATGAGCCATTGCACCCAGCCTCTATTTTCTCCTTCT
GAAATTCCAATTAGAAATATCATGGAACATCATATATGTCTTCCATGTCTCATCTTCTTTTTTTCCCTTT
TGTCATCTCTGTGGTACATTCTAAACAAATTTTTTAATGATTCTAACGGCCATGCCACAAAATGTCTCCA
TTTGGTTTTATTTGACAATATCTTTTTCTTTTTTTTTTTTTTTTTGACACAGAGTCTCTCTCTATTACCC
AGGCTAGAGTGTAGTGGTGTGATCTTAGCTCACTGCCACCTCCGCCTCTGAGCTCAAGCAATCGCCCTAC
CTTAGCCACCCAAGTAGCTGGGACTACAGGCATGCACCACCACACACAGCTAATTTTTGTATTTTTTGTA
GAGATGGGGTTTTGCCATGTTGCCCATGCTGGCCTCCAACTCCTGGGCTCAAGTTATCTTCCTGCCTTGG
CCTTCCAAAGTGCTGGGATTACAGGCATGAGCCACCACTCCCAGCCAACAATATCTTATTCTTTTACCTG
TTTTAGAGTCCTCTGAGTACTTCTTTAATCAACTTCAGTGTACTTATTTGAAAATTTTCACTAGTAATCC
TTCCATCTGAAGTTGTTGGGGGCCTGATTTTGCTGTATTCTTTAACTTTCTTGCATAATATTTGCTTCCT
TGTGTGTTTTGTAATTTTGAATTTTGAGCTCTTGTTTACCTTGTTCTTCAACCCAGGACACTCAGTCTTC
AAGAAGAGAGTATGTGGATAGGCTTTTCCAGGCATCTTAGGACTGATAACATCTCAAAATCACTTTGTGC
TCATTTCTTGGCATAGAGTTACCTGGGTCATGTATGTTGTGAGTTTTTGAATCATGAACCCACATAAGGA
AAACCTTTGATTATGTTGGTTATGACTTTCAAGGAGTACTATTTTCCCCTGCTCAGAGCCCAAGATGAGA
TGTACAAGTTTCTACGTCAGATAGTTACTTTGGCAGGCAGGCAGATATTTGTTTTTGTCCATCCTTTCAA
TAAAGGAATCATTCCTTAAGGTTCCTAGCTATATGCACAGATCTCACTCCAACCTCCACATCTTGTCTTT
CTGTCCTTCATGGTCTTTAAAATCTAAACCCCTTGGATATCAAGATTGGGACATGTTCCAGTATCACCTC
ACCACTCCAGTTTTCAGTTACTTGATTTTAGTTTTTATTTTTTAAATGCTTTTTTTAAAAGAGAAGTTTT
ATGCTCACAATAAAATTGAGCAGAAAGTACAGAAAGTTTACATATACTCCCTGTCCTGATACATGCATAG
CCTTCCCTGTTATCAATATCCCAGACTAGAATGGTATGTTTGTTATAATCAGTGAACCTGCATTGACACA
TTATTATAACATGAAGTCCATAGTTTACATTAGGATTCACTTCTTTCTCCCTTAACACTTGGCAACCACT
GATCATTTTACCATCTCTGCAATTTTGCTTTTTCCACCACTGGAAATGTTACATATTGGAATCATACAGT
ATGTAGCCTTTACAGATTGGTTTCTTTCCTTTAGTAATATACATCTAAGGTTCCTCCATATCTTTTCATG
GCTTGATAGCTCATTTCTTTTTAGCACTGAATAATATTCCATTGTCTGAATGTATCACACTTTATTAATC
CATTCACCTACTGAAGAATATCTTGATTGCTTCCAAGTTTTGGTAACTATGAAAAAAACTGCTATAAACA
CTCCTGTGCAGTTTTTTTGGAGACATAAGTTTTCTACTCCTTTGGGTAAATACAAAGAATACGATTGCTG
AATCATATGATAAGAGTATGCTTCATTTTGTAAGAAAATGCCAAGCTGTCTTCCAAAGTGGTTGGATCAT
TTTGTGTTCCCATCAGCAATGAATCAGACTTCCTGTTGCTCTATATTCTCAACAGCATTTGGTCTTTTTA
AAAATTGTTTTGGGCCGGGCGCGGTGGCTCACACCTGTAATCCCGGCAATTTTGGGAGGCCGAGGTGGGT
GGATCACCTGAGGTCAGGAGTTTGAGACAAGCCTGACCAAAATAGAGAAACCCTGTCTCTACTAAAAATA
CAAAAATTAGCCGGTCGTGGTGGCAGGCGCCTGTAATCCCAGCTACTCGGGTGGCTGAGGCAGGAGAATT
TCTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCCAAGATCGCACCATTGTACTCCAGCATAGGGGACAAG
AGCGAGACTTCATCTTCAAAAAAAAAAAGTTTTGTTTTTTTCCTTTCACCAAACTAAGCATTTAGTCTTG
TCAGTGTTTTGGATTTTGACTATTCTAATAGGTGCATAGTGGTATCTAATTTTTAATTTGCAATTCCCTT
GTGACATATGATGCTGAACATCTTTTCATAAGTTTATTGCTATTTGTGTATCTTCCTTGGTGAGATGTCT
GTTCAGATCTTTTGCTTATTTTATTTTATTTATGTATTTTTTTTTCGAGTCTCACTCTGTCACCCAGGCT
GGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTAAAGCAATTCTCCTGCCTCA
GCCTCCCGAGTAGCTGGGACTACAGGCACGAGCCACCACACCCAGCTAATTTTTTGTATTTTTAGTAGAG
ACGGGGGTTTCACTATGTTGGCTAGGATGGTCTTAACCTCTTGACCTCGTGATCTGCCTGCCTTGGCCTC
CCAAAGTGCTGGGATTATAGGCATGAGCCACCATGCCCGGCCTTTTGCCTATTTTTTAATCAAGTTGTTT
ACTTTCTTATTGTTGAGTTTTAACAGTTCTTTGATATTTTGGATAACATTCCTTTATCTGATAAATCTTT
TGCAAATATTTTCTCTCAGTCTGTAGCTTATCTTCTTCTGTTCTTGATAGTTTCATTTGCAGATCAAAAG
TTTTACATTTAGTGAAGTGCAGTGTATCAATTCTTTCTTTTTTGTCCAACACAAGATCATCTAGCTATTC
TCCTATGTTATCTTTTAAGAGTTTTATAGTTTTGTACTTTATATTTAGATCTATGATCTGTTTTGAGTTA
CTTCTTGTGAAGGGTATAAGATCTTTATCTAGATTTGTTTTTTACATGTGGGTGTCCATTTGTTCCAGCA
CCATTTGTTGAAAAGACTGTCTTTGCTCCATCACATTGCCTTTGCTCCTTTGTCAAAGATGAGTTAACTA
TAGCCTGGTGTGCAGTGGTACACACTTGTAGTCCCAGCTGCTCAGTAGAGTTCAATAGTTTTCTTTAGGA
GGCTGAGGTAGAAGAATTGCTTGAGCCTAGGAATTTGAGTCCAGCCTAGGCAACATAGCGAGACCTCATT
TGTAAAATAAATAAATAAATAAGACCAGTTGACTGTATTTATGTGGGTCTATTTCTGGATTCTCTATTCT
GTTCCATCTATTTGTCTGTTCTTTGGCCAATTGATAAAATATCATGTTGTCTTGATTACTACAGTTTTAT
AATGTCTTGAAGTTGGTAGTGTGAGTTTTCTGACTTCATTCTTCTTCAATATTGTATTGGCCATTCTTGG
TCTTTTACCTCTCCATGTACAATTTATTTTTATGTATTTATCTAGAGACAGGTCTCGCTCTGTCATCCAG
GCTGGAATGCAGTGGCGTGATCATAGCTCACTATAACCTTGAACTCCTGGGATCAAGTGATCTTCCCACT
TCCATCTGCTGAATAGCCAGGACTATAGGCACACACCGCCTTGCCCAGCTAACTTAATTTTATTTTTAAT
TTTGTAGAGAATGGGGTCTCTCTATTTTGCCCAGGCTGGTGGTCTCAAACTCCTGGCCTCAAATGATCCT
CCTGCCTTGGCCTCTTAAAGTGCTGAGCTTACAGGCATAAGCCACTGCTCCATATGCAGTTTAGAATCAG
TTTGTTGATACCTACAAAATAACTTGTTGGGATTTCAGTTGGGATTGTGTTGAATCTATAGATCAAGTTG
TTCGCAAGAACTGACATCTTAACGATATTGAGTCTCTGCATTTATTTAGTGCTGCTTTGATTTCTTTCAA
CAGAGTTTTGTAGTTTTTTCATGCAGACCTTAAACATTTTTAAAAGATTTATACCTAAATATTTCATATG
TAGGGTACGAATATAAATAGTATTATGGTTTTTAAAATTTTTTTCTTTTTTATTTTTTTGAGTCTCACTC
TGTCACCCAGGCTAGAGTGCAGTGGTGCGATCTCGGCTCACTGCAAGCTCCACCTCCCGGGTTCACGCCA
TTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGACGCCTGCCACCACACCTGGCTAATGTTTTGT
ATTTTTCATAGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTCGTGATCCACC
TGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACTGTGCCCAGCCAATAGTATTATGTTTT
AAATTTAAAAGTCCACTGTTTTTTGCTGATATATGAGAAATAAATTGATGTTTGCATATGAACCTTGTAT
CCTACAACATTGGTATAATAACTTATTAGTTCCAGATATTTTTTATTAATTCATTCCAATTTTCTACATC
GATGACAATTTCATCTGTGAACAAAGGCGGTTTTATTTCTTCTTTCCCAGTTTGTGTATCTTTTCTTTGC
TTTTTGCATTAGCTAGGACTTACGGTATGATGTTGAAAAGCAGTGGTGAGAAGGGACATCATTACCTTGC
TCCCGATCTTTGTATAAAGTCTCTAGTTTCTCACCACTAACTGTGATGTTAGCTGTAGGTGGTTTTTTAA
ATCAAGTTGAGCAAGTTCCCCTCTATTCGTAGTTTACTGAGAGTTATTATCATTCCAAATGGGTATTGTA
CTTCGTCAAATACATCTATTTGACATCTATTTTTCTGTGTCTATTGATATAATCATGTGATTTTTCTTTT
CTTTTTTTGAGACAGGGTATCACTCTGTCACACCAGCTGGAGTGCAGTGGTACAAACACAGCTCACTGCA
GCCTCCACCTCCTAGGCCATGTGATCTTTCTTATTTAGCCTGTTAATGTGATAGATTACATAAATTGATT
TTCAAATATTGAACCAACCTTTCATACCTGAGATAAATCTCACTTAGTCATGGTGTATAATTTCTTCTAT
GGATTGTTAGATTCAATTTGCTAATATTTGTTGGTGTAAAAGTCATTGTGGTTTTTGCCATTGAAAGTAA
TGGCAAATGACTTTTGCACCAACCTAAGGATTTTGCTAAGGATTATTGCATCTATATTTATGAGAGATAT
TGCTCTGTAGTTGTATTAGTCTGAATTCTCTAGGGAGATACTGGGAGAACCCACCCCCAATATTTCAACG
TAAGTTCTATTTTCCATAAGTGTCAGCTGGCTGAGAAATAAAGAGAGACAGTACAAAGAGAGGAATTTTA
CAGCTGGGCCGCCAGGGGTGACATCACATATCAGCAGGACCATGATGCCTGCCTGAGTCTCAGACCAGCA
AGTTTTTATTAAGGGTTTCAAAAGGGGAGGGAGTGTAAGAACAGAGAGTAGATACAAAGATCACATGCTT
CAAAGGGCAAAAAGCAGAACCACTGATAAGGGTCTAACAAAGATCACATGCTTCTGAGGGAACAGGGCAA
AGGGCAAAAGCAGAACCACTGATAAGGGTCCAACAAAGATCACAGGGCAAAGGGCAAAAGCAGAACCACT
GATAATGGTCTATGTTCAGCGGTGCACATATTGTCTTGATAAACATCTTAAACAACAGAAAACAGGGTTC
AAGAGCAGAGAACCAGTCTGACCACGGATTTACCAGGGCTGAGTTTTCCCAACCCTAGCAAGCCTGAGGG
TTCTGCAGGAGACTAGGACTTATCTCAATCCTTACCTCAACTGCACAAGACAGACATTCCCAGAACGGCC
GTTTATAGACCTCCCCCCAGGAGCGCATTCCTTTCCCAGGGTATTAATATTAATATTCCTTGCTAGGAAA
AGAATTTAGCGATATGTTTCCTACTTGCACATCCATTTATAGGCTCTCTGCAAGAAGAAAAATGTGGCTC
TTTTAGCCCAACCCCACAGGCAGTCAGACCTTATGGTTGTCTTCCCTTGTTCCATAAAAATCGCTATTAT
TCTGTTCTTTTTCAAGGTGCACTGATTTCATATTTTTCAACTACACATGTTTTACAATCAATTTGTACAG
TTAGCACAATTATCACAGTGGTCCTGAGGTGACATACATCTTCAGCCTACGAAGATAACAGGATTAAGAG
ATTAAAGACAGGCATAAGAAATTATAAAAGTGTTATTTGAGAACTGATAAATGTCCATATTAAGATGAAA
TCTTCACAATTTATGTTCCTCTGCCGCAGCTCCAGCTGGTCCCTCCATTCAGGGTCCCTGACTTCCCATA
ACAGGGAGACAGTGCCAATGGGATATATATAGAGAGATATACGAAAGAGATTTATTAGAGGAATTGGCTC
ACACAATTATGGAGGCTGAAAAGTCCAATAACAGGCCATCTGCAAGCTGGAGACCCTGGAATGTCAATGG
CATAACTCAGTCCAAGGCCGAAGGCCTGAGAACCCAGGGGGCTGCTGGTGCAAGTCCTGGAGTCCACAGG
CCAGGGAGTTCTAACACGCAAGGGCAGGAGAGGAAGGGTATATCCCAGCTCCTGCAGATAAATCAACACA
CTTGCTTTTTCTGTTTTCGTTCTCTCTTGTCTCTTGGCTTATTAGATGGTGCCTGCCCACATTGTGAGGG
TGGCTCATCTTTACCTAGTGCACTTAGACTCACACACTCATCTCCTCATGCTGATCACAAGCACATCCAA
AAGTAACATTTTACCAGGTTTCTACAGTGTTCCTTAATCCATTCAAGTTGACACCTAAAATTAATCCTCA
CAGTAGTTTTCTTTTCTTGTAATGTCTTTGTCTGTTTCAGTATTGGGGTAATGCTGCCCTCATGGAATGA
GTTAAGAAGTATTCCCTCTGTTTCTGTCTTCTGGAAGACATAGTAGAGAATTGGTATAATTTATTTCTGA
ATGTTTGGTAGAATTCACCAATGAACCCACCTGGACTGGGTGATCTCTGTTTTAAAATATTTTGAATTAT
TGATTCAATTTCTCTAATACATATAGGCCTCTTCAGATTGTCTGTTTTTCTTGTGTGAGTTTTAGTAAAT
TCTGTCTTTTAAGAAATTGGTTATCATTTTCTTTTTTTTTTCCTTTGAGATGGAGTTTCGCTCTTGTTGC
CCAGGCTGGAGTGCAATGGTGCGATCTTGGCTCACTGCAACCTCTGCCTCCCTGGTTCAAGCAATTCTCC
TGCCTCAGCCTCCTGAGTAGCTGGAATTACAGGTGCCCACCACCACGCCTGGCTAATTTTTGTATTTTTA
GTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCTGTCT
CAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGTCACTGTGCCCGGACATCAGTTTCTTAAATTGACAT
CTAGGTTATCAAATTTTGGGGCATAAAGTTGTTTATAATATTCCTTTATTATTCTTTCGGTGTCCATGGG
ATCTGTAGTTATGTGCCCTCTTTCATTGCTCATGTCAGTAATATGTGTCTTCTCTATTTTTTTTTCTTAG
CCTGGCTAGAGGCTTATTGATTTTTCTTGATCTTTTCAAAGAACCAGAATTTAGTTTCATTTTTCTCTAT
TGATCTCCTGCTTTACATTTCATTGATTTCTATTCTAGTGTTTATTATTTCTGTCATTCTTCTTACTTTG
GAATTAAGTTGCTCTTCTTTTTCTAGTTTCTTGAAGTAAAACTTTAGACTACTGATCTTATATCTTAATT
CTTTTGTACATTTCTCTTGAGATTTCTTTTCTGACCCATTTGTTATTTAAAACTGTGCAGTTTTATTTCC
AAGTATTTTGGGTATTTCTTGCTAAATTTATGTTATTGATTTTTAGTTTAATTCTACTGTGGTCTGAGAG
CAGATATTGTATTATTTCTACTCTTTTAAATCTGTTAAGTTGTGTTTTATGGCTCACAGTGTGTTTTGTC
ATGGTAAATGTTCCATGTGAGCTTGAGAAGAGTCTGTACTTTGCTGTTATTAGATGAAGTAGTCTATAGA
TGTCCCTTGTATACAGTTGATTGATGGTGCTACTGAATTCAACTATGTCCTTACTGATTTTCTGCATTCT
GGATTTTATCCATTACTGATAGAGGGGTGTTGAAGTTTACAGTTATAATAGTGGATACATCTGTTTCTCT
TTGCAGTTCTGTCCATTTTTGCCTCATGTATTTTGATGTTCCATTGTTGGCACAATGCACATTAAGGATT
TTTATTTCTTGTTGAATTAACCCCTTTATCATTTTGTGACCCACTTTTTAATCCTGATAACTTTCCTTGG
TCTAAAGTCAGCTCTGTCTGAAATTTATGTAGCTATTCTTGCTTTCTCTTAATGACTATGTTAGTCTGTT
TTCATGCTGTTAATAAAGACATACCTGAGACTGGGTAATTTATAAAGGAAAGAGGTTTAATGGACTCACA
GTTCCACATGGCTGGGGAGGCTTCACAATCATGGCAGAAGGCAAATGAGGAGCAAAGGCATGTCTTACAT
GGTAGCAGACAAGAGTTTGTGCAGAGGAGCTTCCATTTATAAAACCATCAGATTTCATGAGACTTATTCA
CTACCATGAGAACAGTATGTGGGAAACCACTCCCATGATTCAATTATCTCCACCTGGCTCCACCTTTGAT
ACATGGGGATTACTACAATTCAAGGTGAAATTTGGGTGGAGACACAGCCAAACCATATCAGTTACTATTA
GGATGGTATGTCCATCCATTTACTACACAATCTACATGTGTCTTTATAAAGTGGGTTTCTTGTAGACAAC
ATATAGTTGAGTCATGTTTTTTATCTACTGTAATGATCTCTTGTTTCGAATTGATATATTTATACCATTG
ACTTTTAAAGTGATTATTGATATAGTTGGATTATTATCTATCATATTTGTTACTTTTTTCTACTTGCTGC
CTTTGTTCGTAGTTCCTGTTTTTGTCTTCCAGTCTTTTTCTGAGTTTTGGTGTTTTAATTGAACATTTTA
TGTGATTTTGTCACATGATTTTGTCTGAAAGTATCTTATTTCTCTGCTTTTGAAGGTTAATTTTGTAGGA
TGTTTATATGGTTTGGCTCTGTGTTCCCACCCAAATCTCATGTTGAGTTGTGTGGCCTGGTGGGAGGTGA
TTGGATCATGTGGATGGTTTCTAACAGTTTAGCACCATCCCTCTAGTGTTGTGTCATGATAGAGTTCTCA
TGAGATCTGGTTGTTTAAAAGCGTGTAGCACTTCCCACTTAGCTCTCTCCATCTTCTGCCACCATGTGAA
GATGTGCTTGCTTCCCCTTTGCCCTTCTGCCGTGATTCTAAGTTTCCTGAGGCTTCCCAGCCATGCTTCT
TGTACAGCCTGTGGAACTGTGAGTCAGTTAAACCCCTTTTCTTCATAAATTACCCAGCTTCAGGTAGTTC
TTTATAGCAGTGTGAGAATGGACTAATACAGACGCACAATGCTAGGCTGGTACTTTTTTCCTCTCAACAC
TTTAAATATTTCACATCACTGTCTTATTGTTTACATGATTTCTGAGAAGTCAGATATCTTTCTTATCTTT
GCTCCTCTATAGATAAGATGTTTTTTCCCTCTGGCTTCTTTCAGGATTTTTTCTTTATCTTTGCTTTTCT
GTAATTTGAATATGATTTGCCTACATGTAGATTTTTTTATTTTTTATTTTCGTTTTTGGCAGTTAACCTG
ATTGGTGTTCTCTGAGCTTCCTGGGTCTGTGGTTTAGTGTCTGATATTAATCTGGGGAAATTCTCAGTCA
TTATTGCCTCAGATATTGCTTCTATTCTTTCTCCTTCTGGTATTCCCATTGTACATATTTATAACTTTTG
TAGTCCACTGTTTGTTGATTTTTTTCTTTTTTTCAGTCTTTTTTCTCTTTGCTTTTCAGTTTTGGGCATT
TCTATTGTCATATTCTCAAGCTCAGGGATTCCTTCCTCAGCCATGTCCAATCTACTAATGAATCCATTAA
AGTGATTCTTCATTTCTGTTAGTGTTTTTTAATCTCAGGCATTTCTTTTTTTATTCTTTCTTAGAATTTC
CATCTCCCTGCTTAGATTACCCATCTGTTCTTGCATGTTGGCTGTTGTTTTTTTTTTCAGTAGAGCCTGT
GGCATATTCATCATATTTATTTTAAATTGCTAGTCTGATAATTACAACATCCCTGCCATATCTGACTCTG
GTTCTTCTGGGAGGTTTTTTGAGACAAAGTCTCCCTCTGTCACCTCCCTCTGTCACTGCTGGAGTGCAGT
GGTGTGATAACAGCTCACTGCAACCTCCGCCTCCTGGGTTCCAGCATTTCTCGTGCCTCAGCCTCCCAAG
TAGCTGGGACTATAGGCGTGTGCCACCAAGCCTGGCCAATTTTTGTATTTTTAGTAAAGACAGGGTTTTG
CCATGTTGGCCAGGCTGGTCTTGAACTCCTGGCCTTAAGCTCCTTAGCCTCCCTAAGTGCTGGGATTACA
GCCATGAGCCACCGCACCTGGCCTAACTCTGGTTCTGATGCCTGCTCTGTTTTCAAACTCAATTTTTTAC
CTTTTAGTATACCTTGTAATTTTTTGTTGGAAGTTGGACTCGATGTACTAAGTAAAGGAACAGCAGTAAA
AAGGCATTTAATTGAAATGTGGTGGGAGGGAATGTGTTCTATTGTCTTTAGGGATCTTTAGGGAGCCTGT
GTTTATGGACTGTGAACTTTACAAGTGCTTCTCAGCCCCCAACCCCACTCAGGCGGGACAGAATGGGGCT
AGAGTTGGGTATTTCCCTTCCCCCAGGTCAGTTAAGCTTTGATAAAACCCCAATAGGTAAAAATAGTTTC
TCTGGAGGAGAGGCCTGCTAAAGACCAGAATGCTTTGTTTCCTTTCCCTCTTCCTCTGGCAGAAGCATGG
GAGGATTTTTTTCTCCAGTCTTCATTGTGAGAACCTGGTAGAACTCCTAGAGGTAAAACCTACAAAAGTG
CGGGTGCCTCCATCTAAGACTGGGTCCCTCTGGAGTTGTTTTTTGTTTGTTTGTTTGTTTTGTTTTGTTT
TTTCTGTTTGTTTTGAGACGGAGTCTCACTCTCATGCCAGGCTGGAGTGCAGTGGTGCGATCTCGGCTCA
CTGCAATCTCCACCTCCCGGGTTCAAGCAATTCTCCTGTCTCGGCCTCCCAAGTAGCTGGGACTACAGGC
ACCCGCCCCCTCGCCCAGCTAATTTTTTGTATTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGAT
GGTCTCGATCTCTTGACCTCGTGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGC
CACCACGCCTGGCCCAGTTTTAATTTTTTATTTTGCATATAAGTTCAAAGCCTTCCAAAGTGTTTGTTTA
TGATTTATTTTCTTGTTAAAATCTGTTCTTGTTCATTGCCTGTTTATAAGTGTTGTCTTGATGTTTATTT
TTTGCATGTACATTTTAATTTGTCAATCTGTTTCTTCTTTTATTTCAACTGTTCCAAATTTTAGAAAGTT
GTTTCAAGTATCTGATACCTAATTCTAATTTATGCTAGCTTTTCTAACATTTGATATTCAACTTCTGATT
TTGAGTTTATTTTTGTGTATGGCCTAAGATGCTATTATTCCTGTTGTTATTCATCCATCCCAGTATCATA
TTCAATCAACCTCCCCCACCACCACCACTATTTTGAGTGTGGTTGCATTAAAAAGCATGTGGGCTTTTGG
TCAGAATAGATTTGGGTGAAATCCTGGCTATGGGTAGCAGTCTCCTTCTACTTTAAGAGTAACTTCTTCA
CAAAAGGAGCTAGATGATCCTCTGCTTTGCCTCTAATGCTGAGGAATGTTGCACCTACAACTATCATGGA
AGACGCTGAAACCTCCATTACCCAATCCTGTACTCCCAGCACCCTCAGGGAGCCCCACCTCTGGAGGACT
CAGACACTCATGCCAGGTAAAGCTGTAGGACAGAGGCCAGGCATGGTGGCTCACAGCTGTAATCCCAGCA
CTTTAGGTGAGAGGATTGCTTCAGGCCTGGAGTCGAGACTAGCCTGAGTCACATAGCAAGACCCCATCTC
TACAAAAAATTAAAAAATTAGTCACACATGGTAGCATGCACCTGTAGTCCCAGCTACTTGAGAGGCTGTT
GGGGAGGGATCACTTGAGCCTAGGAGTTTGAGGCTGCTGTGAGCTATGTATGATCATGCCACTGTACTCC
AGCCTGGGCAACAGAGCAAGACCCTGTCTCAAAAAAAAAAAAAAAGAAAAGAAAAGAAAAAGAAGCTATA
GGACATAGGGGAGCTAGTCATATGTCTGTCCTACTGAGACTCTAGATGGCACAAGGCAATGGCACTTGTG
TTAGAACCAGAATGCAGCTATGGCTGACTTGGAACCGTCTGTCAGAGGAAAAAAGGCATGCAAATAGTTA
CTCATTTGACCAAAGCAGAAGAAAACCAAAATGTCCAATGCCTCCAGGAAGAAAGGCAAAGATAGAGATA
CTAATCATTTCTCTACACATCTGCCATGCCATGGGTGAAGAAGACAGCCAAGTTGGTGAACAGATCTGGA
AAGGTTACCATCATTCTTGATTGAGCTCTGCCCTCCAACCGAACACCCCTGAGCAGCCACGGCATGCCGG
CTCACCGTGCTTCCCACCACGCATGGATCAAGAGCACCTCCACAGGTTCTCAGAAGCTACGGCACCAGGA
CCCATTTGCCTGCTTTTTGCTGTTCCTCTTAAGACAGGGTCCTGCAATCACAGCTCACCGCAACCCCTGC
CTCCCAGGCTCAAGTGATGCTCCCATCTCATCCTTCCGAGTAGCTAGGACTACAAGTGCATGCCACCATG
CCCAGCTAATTAAAAAAATTTTTTTTTGGTAGAGACAGTGTTTCTCCATGTTGCCCAGGCTAGTTTCAAC
CTCCTGGGCTCAAGCAATCCTCCTGCCTCACCCTCCCAAAGTGTTGGGATTACAGGCATTAGTTACTGTG
CCTGGCCTCTCTTGGTAATTTTGACTATGCCACTCCTAAATATATGCCTCTTGGCCTCTGCATGAGAGAA
GGTGGCCTTTGATGTGTTATTTCCAGCACTGTGGTTTACTTTAGCTTTTTAAATTGTTTCTTTCATAATT
TCTACTATCATCCAGCGTCAGTGTTTCTAGCCTATCCTATTAAGGGTTATTCTTTTGTTTTGTTTTGTTT
TGTTTTTTGAGATGGAGTTTCGCTCTTATTGCCCAGGCTGGAGTGCAATGGCACGATCTCGGCTCACTGC
AATCTCTGCCTCCGAGGTTCAAGCTATTCTCTTGCTTCAGCCTCCCAAGTAGCTGGGATTACAGTGCCTG
CCACCACGCCTGGCTAATTTTTTGTGCTTTTAGTAGAGTTGGGGTTTCACCATGTTGGCTAGGCTGGTCT
TGAACTCCTGACCTCAGGTGATCTACCCACCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCAC
CATGCCCAGCCCCAAGGGTTATTCTTTTGATTTGGGGAACAGGGTTCCTTGGCCCTATTACCCACCACAT
TGTTCTCCACTCTTTGCATCCTGAGCATCTCCATCTGCATTTTTCACTCCTGAGTACTGGCAGAGATGAG
CACAAGGGTAATGGGACTTGATGTAGTGACATTGTATCCACCACATGCTTAGAGAGGTTACATCCACCAC
AAGCTTAGAGATTCTGTATCCACCACAGGCTTAGAGAGGTTGTATCCATCATACAGTTATGTTGCATCCA
CCATACATCTAGAGATGTTGTGTGCACTATACAATCAGCAATATTGTGTCCATCATACATTTAATAATCA
CAAAGCCATTACATGGCCCACATTTCTGAGCACATCTTCCCTGAAAATTTTGACACGTAGTTCTAGGACA
TCACATTTTCCATGCACTGGTTCTTTTTCTTCTGGATGTCAAGCCCTCAGGTCCACATTATCTAGAAGGT
GTTCTTTAAGGTAGTCCAAGAAGGAAATGGGTAAGAAATTTCCCAAAGGCTTTTAAAAGCAATACCTTGC
TGACACTCATTGAAACTCATTTCAGAGAATTTGACGATGGTTTTTGGAAGCCATAAGCATTCCAGAAGAA
CAGAGTAGCTAGAAGTGCCCCCACCATTCATGTGTCCCAGGACTGACTGACAGTGGAAAAGCTTTATGTG
TGTGTATTTTCCTTGCTGCCTGGTCAAGGTCTCCAATCAATAGTTTAAGACTTTTTCACAGTTCATTTTC
GACCACCGAAGATTTCCTTTAACTTTCCTGCAAACTCAAATATGCATTTAAAAATAATCTGTTTCATTTT
TGCAGGATATGGTTGAAACATTTTTCAGATTATCTAGTCTACCATATTGCCCCCCACCTTTTTTTAAATC
AGGAATTTTATTTAAGTAAAAACCAATAACAACCTGGTTCTTCAATGGTATTCCTGCCATAGCTAAGACA
AGCACTGAGTCCTTTAACTGACCTGCATCAAATTGTTTAGGGGAGATTTTTCCTTCTAGTTTGAGTGTTT
AATGCTTTCTTTGCTGCTTATTTTCATTAAATATGGTAGAAATACTTTGAAATCTGCCCAGATTCCATCA
GCCCTATTGGAGAGGCACCTGAGAAATGAAGATGATGTTTCTGACTCATAACTTTCTTTGACATAAGGGA
ACAATAGGAGTCAGAATATAGGATATACATTCCTCTATCTTCTACTCAATTGGTTCTCCAAGTGTGACTC
AGACCAGGAGCATCAGCATCACCTTGGAATTTGCCATAAAATGCAGATTCTCAGACCCTATTCCATACCT
ACTCAATCAAAACTTCCAGGCATGGGCTCCAGAGATCTGTGTGTTCAAGCCTTCAGGTGACTCTGATGGC
GTGCTTACATTTGAGACCCTCTGCTCTGGTCTGATCACCCAGAATCTCCCTTGGGAGAGCTACCTTGAAA
TTTCTGCTTATTTCCCCTGCAGCGTATTGAAGACTCCACGGTGGTTGTTTTGTTTTGTTTTGAGATGGAA
TCTCACTCTGTCACCCAGGCTGGAGTGCAATGGTGCGATTTGGGCTCACTGCAACCTCCGCCGCCCGAGT
TCAAGCGATTCTCCTGCCTCAGCCTCCCGGAGTAGCTGGGATTACAGACACGTGCCACCATGCCCGGCAA
ACTTTTTGTATTTTTAGTACAGACAGGGTTTCACCTCCGCAGTGGTCATTAAAGCTTGACCACTAAATTG
CCCTGGTTCTTCAACATGCACTAGGCAGGCTGGACCAGAAGCCAGGAGACCTGGCTCCCAGTCTCATTAT
CATTACTAACCAGTCCTGGAGTTTTCCCTCACCATGAAGATGGAATTTTTACCATCTGCTTTCTCTGCTT
TGTGTGGCAGGAAGATAAAAAAATAATAATAATGGATATTCAAACGGTTTATATTGCATGTAAAATGCAA
TGTGGCATTGATTGTAGATCCCTTAATTCAGACAGATTTCCCCACGCAGACGCTGTGTGTCACAGGGGGA
ATGGGCAGCGTCACTTTTTACATCCAGTCATATTGTATGAAATTGCAACAAATTCAAAAAGATGCCATCG
TGGGAGTGTGGTGAGTAAAAAACAGCTTTCATGAAACTCAAATCTTGAAAGTCAGATGCTTTCTGGGTCT
TGTTTAACTGTAAAAGAGATAGATGAAGTATTAGAAATGGAGAAGGAAAGGGGGGAAAAGCCATCCATTT
ACTGCTTAAGAATGGCTCTGCTATTGCGATACCTAAGGTCACATGCGTAGCCACTTGGGTTAATGATACT
CAGTTTGTCCACGGAGTGGCAGTAGCAACTGTCTGAGAATCAGTCTCAGCCGGGGTTCCTTCTGTCTATA
GAAAGTGAAAGACAGACTGTTATTCAAATTCCATGTGCAAAAAAGCCTTCTTACATTAAATACCTGGGCA
TTTCAGGAAGAAGTTTTATTTGACTTAAACTGTGAAGGCAGTTTCTCATTTGAGGAAAAGAAAGATATAA
CGTGTTTCAGTTGAAATGTCAAGATCCTTTGATTGCACATTTGGTTTCCTAGGATAAATTATTCTAGCCA
ATGGAGCAGAAACTGGCTAATCAAAGGCACAGTGCACAGTTACACTTCTGTATATCATTCTCTTTTTTTA
AAATAATAGCTGGAATTTTTTTTGAAAGTGAAATTACAATTTACCACCTCAACTCAGAGGACATATTAGC
TTGATAACTTATTCACAGTTGCTGGTGAGTTCAGGCTTAAATCATCAGCTGTCACTCACAAGTGTTTACC
CTTGAACTTTCCGAATGAGACATCAAACGTCTTGGTAGTGGGTGGGTTTAAACAAAGCTGCCCACGCGAG
AACCATTGTGGAGCTTCTTGTTCCAGGGGCCGGTCACGGACAAGCTCATGACCAGCACACTCAGATGTGA
CAATCAGATAACAAGAGGCAAGAGAAGACTTTCTGGGAAATAAAAGATCATTTTTGTGATTTCTTTAAAT
TCAGATCATATAAATTAGGTGAAGATAGACATTATTTCTCCTGTTTATGTAAAAGAATTTAGACAATGAA
GTCACGAAATTCATGAGAATAATTTAAAGACTGTTGGAACTTCCCAATGTTTTTCTTGGCATTCAGTCAC
TACACATAGAAATGTATACTATGCCGGTTCCTAATGACTTAGCAGTTCCCTCAGGCTTTGTTCCACAGGA
TGTGACATCTCCTCTGCCAACTTTTCCTGCCTCCTTTCCTAATCATAGGATTGCTATTCTCCCTGACAAG
TAAAGAATGACAAGATATTTTATTAAAAAGATGTTTTATTTATCTTTTAAAGATTTTTTAATGTATGTAT
CTGCCTCTGAAATTATTAAGAATGCCTTAATAATAATCCCTCTCATTTTATTTCAGAAGACACTATTGTA
ATAGCATGGCTAGGAAGGAAACACAGCTAATTATTAAGATGAATCATTTAGCAAGGTGGGGAAAAATCCC
TTGTGTGTAAAAATATCTAGTGATTGACATATTACCAAATTTACATGAAATAGATTTCCATGTAATTGAG
ACTGATTTTTCCTATTAGATGGAAAGAACCTTCCTGATCAGGACTGGTGTTGGGGGAATGTTTTCCTTAT
GAAATCAGAAGCAGAGCTTCTGTAGGGCCGTCCAAGATCAGGATGCTTACTTCAAGATGCCACTCTGCAT
CTCTCCCCACCTGCCAAGTGTTTCCTGTCTCCCAGATGCTTTCTATTGGCTTATTGTAAGGACTTTGACT
TCTGCGCTACGTGAACTGGGGAGTCACTGGAAGAGTTTCAGAGGTGCACCTTGGTAGACTCAGGCTTTCT
CTGGATCTCACTGGCTGCTCTTATGAGTCCAGAATGGAAGAGGATGAGGACAAATGCAGGGGGATGTTAG
GAGACCACTAAGCAGGTCCCTGTCATTTCTCTCTCTGTGATTCCTTTTGCTGCCACTTTCTCCTTGTCCC
CTTGGCTCCAGCCCCCTGCTGTCCTTGCTGTTTCTTGCACCCGCCCGTGAGGCATGCTCCTGCCTCAGGC
TCTCTGCCTGCCGTGCTCTCACCTCGCAGACCCACGTGATTTCCTCCCGAACCCCCTTCAGGCCTCGGTC
CAAACATCACCCTCTCATCGAGGTCTTCCTTGACCACACTGCTTAAAATTGTCCCCCTCGCCTCACCTTA
CCACCTTCACTGCCTCATTTCTCCTTTGTGCTTAATCACCATCTCACACAGTTATCCAGAGCACGAGCCC
CACGAGGAAGGGTCTGTCTTGTCCACTGTTGGACCCCTGACACCTAACCCCTGGGGCTGGCCCACAGTTG
GGAATTGCATGGCTGTCTGAAGCCAGCACCTTCCTGGTTCTGCTGTTCCCTGGAAGTGGGGTTCAGTACA
CCCCACGAGCCAAGGCCCTCATCTCAGAGGGCGTGCACATGGTTGCCTCAATTGTGCTTTCACACTGGAC
CCTTCCTGCAGTTTACTCTCCTATGTCAGATGCCCTTCAATGAAAGCAAGTACATTGCCACCTTGTCACA
CCTCTAGTTACCATTTTCTTTATGGTCCAGGTCCTGACCAGCTCTAAAGATGGGTCAGCTGCTGTATTTC
CAAGAACCCCATGACTTCCAGGGCCCCTTGTTCCCAGGAAGGCCCCGCACCCCAGTCGTCCCGTGCATAA
CCTCACGGGCCAGCACCTGGTAGCTGCTGGAAGGCTTCTGGGGGATGCCTGGGCCCCTCCAGCCCTACCT
CTAGTCCTGCCACTTTACAACTGAGCACCTCCCGCTGCTGCCTGCTGAACCCTTCAGAGTCCTTGCCACA
GGCCCTATTTACTTTTTCCTGAGAAGGTATGTGTGATGCCAAAGAGAGAAAAGCAGCATTTGCTAATTTG
GGTAAAATGTTTCTTTGGGAAGGGCAAATTGATGTACAGTTGTCCCTCAGTATCTGTTGGGACTGGTTCC
AGGACCCCGTGGATACCGAAACCCTCAGATGCTCAAGTCCCTTATATCAAATGGTGTAGAATTTACATGT
AACCTAAACACTTCCTCCTGTACACTTTAAATCATCTCTAGATCCCTTACACTACCTAATACAAACTAAA
TGCTATATAAATAATTGTTATACTGTATTTTTTAAATTGCTATTATTTTTTATTGTTGTGCTATTATTTT
TATTGGGCTCCCTCCTCCCCCTCCCACCCCAGTAATTTCAATCCAAGGTTGGTGGAATCCATGGATGCAG
AAACAATGGATACTGAGGGCCGGCTGACTAGACCTATTTTTATTGTAATTACTCATTCTCTTCTACCTCA
TTAAGCTTGGTTCTTTCAAGCATGAATACCTGGTTGAATCTGCATAACCTCTTATTATCGACCTACCTTT
GTTCACACACAAATGATTGCCACTTAGAGCTCTCCTACCGGGCTCCTTTTGTAAAATAAATTTTATCTTC
TCCAGATAGAAAGAAATGTGATACCTTGCGGATTTTGCGGTTTCCTTGTTTTGCTGGATTGCAAGTCCTT
TAGACATAAACAAATGTTCTGTACCCCGACATCGGTGGTACCCAGCTCTCAGTTGAGAAAGAGATGTAAT
GTGAATGCCACTCTTGGCCCCAGGCACTCCTCACTTGCCCCCACTGGGGACTGGTTCATACCCTCCTCTC
CTGGCCTCAGTTTCCATACCTCTTAGTGAGGCCTTTGCGTTATACTTCAGAAATATTGTCAGTATGACTT
TGAAGATGAAAGTTTGCCCCCAAAATCACTCTCTGTTATCATTGTGAAACCAGAGATGGAATGGAAAAAT
GGGTTTCTGAGACATTTTAAATTATTCCTTGCTTGTCTTTAGAGGCAAAATTCAGATAAGAAAGCTTATC
AATTATACTTTTGTTTCTACTCAAAAACTCATGACTGCTCACTCAAAGACTCCTTGTTCTTATCTTAAAA
CATTGTTTACAGTGTCCCAGATGAATGGCAACAAATCCTGGGGTTTGGTGTTTGGATGGTACATTTCCCT
GGGGAAAGAAATAACAGTTTGAGATGGAACCGGGTTGGGGTGGGAGAATACTTCTCATTCTGAGGAATAT
TTAATTTTGCCAAGATGAGCATTTCTAGTTCTTAGTCTGTTGACGAAAAGAGCTATGGTTTGTTTCTGGA
ACTTTTGATAAAAAATAAAGAAATTTGTAGCCTGGGGAGTTTGGTTTTAAAATGCAAACACAGGAGTTAT
GAGTTGAGACTTGGACAGGGTGTCATTTTCTTTTTAAAGGGCAGCAATATGATTCTTTGATTTGTCTTTG
TTATCTTGACTTTTAATCCGGATTCCTGGGCAGTTGTTCAGCCCCAGGACATCTCCATGGGCAGGTGGCC
TGGCCTTGGCACACTACCCAGTAAATCTCTGCCTGAGAGGACGCTTTAGCTGGGAGGCCAGGCTGATTTT
TAAAGGCAGAATTGGACTATTTACTCTAAAACAGTAATGCACACTGTTTAGAAAGAAACATTCCTATTCT
GGGAGGAAGGAGGAGACACACAGAAGTATCATTTATTTCTAGTCTTTTCTGGTAGAAGCTATGAAGCTGA
GTTTACTCTCTGGAAATTTGTAGTTTATTTTCTAGAAAATTGCATTTTATCACTGCAAAAAGGATTTTAT
TTCCAAATGAGTAGGCTTTTGAGCAAGAGTTTTGGAGTCACAGAGATGGGGTTAAGAAAGTGATAATGTG
CAATGGCGATTCTCAAGTTCAAGGAGAAAAAATAACATGCTTTTATTGGGATACTTTGCTTGTCTATAAA
AGAAAGTAGCTATTGGCATTTATGTAGAAGTCAGCAGTTTCTTGGCACCAAATAAATAATTTTGTGCTGA
ATAAAGGGAGAGTTATCCATAGTATTTATTACTAACCAAAGAAATGCAGGGAGAATTGTAATTCATTAGG
TTTTGATGGCCAGGAAAGCCAAGCTGTGTTATTAGGGTCATGACAATCACAGACATTACGGATGGCTGAC
CTGTAGTATGGATAGAGGGCAGAGGGTAGAGTGTGAAATATATCACAGAATTATGTCAAATAATCTGGAT
AGTTACTACTGCTTAAAATCTAAGTGCACAGCTAGAAAAGTGGGTAGTGACGCACTACAGTCTTGCTGAA
CACTGGGTAAGAAAATCATAGCAAACGTTGAGTCTGTTTTGGAAATGTTCTAAAACCAGACTATTAACAC
AGTGAGCCATTTTAAATGTGGCTTGCTACGTGTTTGGAGAGAAACACATACTCTTTTATTAGGAACATGA
AACAAACTCTTTGAGCCGCAGTATCACTGCGAGTGAGTTTAATTGCTGGGATTAATAAATCACAGCTGCA
AACGTTAAATTCTTGGCAGGATTCTTTATTCAGCTGTTTTCCCCTTGCCCCATTACATTCCAGATTTGTG
GTCTGCATTATGTCTGGAGCCAGAAGTAAGCTTGCTCTTTTCCTCTGCGGCTGTTACGTGGTTGCCCTGG
GAGCCCACACCGGGGAGGAGAGCGTGGCTGACCATCACGAGGCTGAATATTATGTGGCTGCCGTGTATGA
GCATCCATCCATCCTGAGTCTGAACCCTCTGGCTCTCATCAGCCGCCAAGAGGCCTTGGAGCTCATGAAC
CAGAACCTTGACATCTATGAACAGCAAGTGATGACTGCAGCCCAAAAGGCAAGAATGCTCCTCGGAACCT
GAGTTTCTCTCATACAGAGCAGATTGCTCTTTACCCCTTGATCAGTGGTTGGGTAATCCCAGGCTTCCTA
CCACCCTCTGAAAAAGCATCCAGGTAGTTAACCTGAGTTGAGTTAGTCAGTTGAATTAGGAGCCTTACCC
CTCAGAGAGTGGTCCGTGGACCGGCATCCCCTGGGAGCTTGTTAGAAATACAAAATCTTGGGCGGCACCC
CAGACCTACTGAATCAGAATGTGCATTGCAGCAGGATCCCCAGGTGATGCTTTCACATGGCAAGTATGAG
AAGCCCAGGACTAGATCCCCAGTTCTCAAGTGTGGTTGTACATAAGAATCACGAGGTAAGTGGTAAACAC
TATGGCTGCCCGGGTCCTGGAGAGTCCGTTGTAATTGGTGTGGAAGGGGTGTGGACTGGCACTGGGATTG
TTTTAAGGCTCCCCAGTGCAGTCTAATGTGCAGAAAAATTTGAAGATGACTGGGCGTGATGACCTCTCTG
AGTCATTCGAAGCTTCACTGAAGTAGTAAGCATCTGCAAGAATGCCGTTTGCTCCCTTCAGACTGTTTGA
GGCTCGTTTCCGGTCTCTATGTCGGACTACGATCAGTCTGAGACCTTCGCCCAGATAGAACTGACCCCAA
ACTGACAAAGGGAAGGTCAGTGCCAGCCTTTGTGAAGGCTTCCTGGTTGGCCTGAATTTCCTGCTCCCTT
CAGGAAGGGTGGGGACAAAGGAGAGGCCCCCCTGGGGGCAAAGAGGGAAATATCAGAGGTTGCCTAAGAA
AATGCCCTGCTGGAAAACACAAACCCGAAGGGAAGTTTGGGCTGTAACTCTGGTGGCAGGGTGACCAAGC
GCAGCTGCTTGAGGAAGCCCTGCTGTGCCTCAACAGGATGTAAACTCATTGTGAGCAACACTTTCCTGCT
CTCTGTGAACTTAAAGGGCAGAACCAGCAGGTCCTGCCCCAAACAGTCCCTGCCTTAGAGCAGGGTGGTC
GGGATGGCCTGGACAGCCACAGCAATTAAAAAATTGCAACATTTTAAAATTTTAGTCTATAATATATATA
CAAAGGCTATGTGTATGGGGTGGGGGGGTGTTTGGGGGCAGGGGGTGTGTATGTGTGTATAACATGATGT
TGAAAGGGAACTTGAAGACTTGGTCCAGCTTCTTTTTTTTCAACCAAGACAACTTTTGCAAGGGTGACAC
TTTTCTTTAGTCCCAACCTGACATACGGTTTCTCCTTGAACACCTTCAGTGGCTCAGACTCACAGGTCCG
TTTGTTCCAATGGTGGGAACTTCTGAACAGGTCTTCCTTTCAATGAGCAGCAGTCAGCCTCCCCGTAACT
GCCACCACGATTCTATCGTCAGAGCTAAAGGGAGCAGGACCGTGTCCCTTATCACGGCATGCCATCTTCT
CCACCTTTGAGGACAGCTGTCATGATCCCCCTGGCATCTGTCCCCCAGGCTGTATCCTCAGTCCCTTCCA
CAGTTCCTTAGGAGACTCAGTTTCCAAACCTTCTACTGAAGACTTCCATGTTTTCTCTGTGCTCAGAACT
GTATGCAGCTATCCCGATTCTGTCTAATAAGGGCAGGGTAGAGAACTCTCACCTGTCGCATTCTAGATGT
TGTCCCCAGAAAACTGCTGGCAGCCACATGTCTCATTATGGGTGTATAAGGCACTTGCTGTCAACTAAAA
CACCTTTTCACATGAGCAGACACACATGCTGCCATTGCCATCCTGTACTTATAAATTATAAAGGTGATTG
ATTTAAGCTGAGGGCAAGACTTCACATTTATGCTGTTAAATTTCATCATTCCAGCCTGTTGGGCTATTTA
GGGATCTTTACTGACATCCCAAGTATCAGTTACCTTTACGTCATTCACACATATGATACACACCTCATTT
ATGTCTATGCTGAAGTCAGTGTAAAAAAACCCCAGGCTGTGCCCTCAGACCTCCTGATGACACTGATCTC
CTAGAGGGCAGGCATTCTCTTGATAGAGATGTTTGCCTGCATGGCACTGAGTCCAGCACCTGAAATGTCA
TCTGCCTCTTGCTTCCCTCCCCTATCCACCGGACCATTCTGAGACATTTGGCAAATGACACACTGAAACC
CAGACTGTGGCTGTAGAATTCTCCTGCATTCACCTTTCAATAATCTGCCCCCAGAGGAAACACTTAACAC
GGTTTTGTTGAAACCACGCCAGCTGCACAGCATCACTCCGTCTCTATTTGTTTTCCAGGGGCCAGGATTA
AGCTGTTGATATGATCACTTTTAGAATTTACAGATATCTCAGCTCCCATACGTGGTTATATGTTTTTTGT
TTGTTTGTTTTCCAGCAGCACTTTTATTTTTCCTTACACGATGACATGTTGCTGGGGCCTATTGTTCTCA
CATAACAGTAGAAAACCAAAATTTGTTGTCATCTCTTCAAAGAATCGAGAATTGCATACAGAAAAACCTT
ACATAAATTAAAAGGATGAATACATTTACAGGTGTAAATGCAAACCACTTTCAACTCAGACAAGTAACAG
CCCATGGTGTTCTGGCAGAAAACATCAGCTAAGAAAGGAAACTGGGTCCTAAGTCTTGGACTTTCCAACC
CTTACAGACCGGCAGAACAGAAACAACTGGTTCAGGAGCCCTTGCCAGCCTCCAGAGAAATCCCAGAACA
CGCAGCCCTGACGTATTAATACCCTGCACAGATCAGAGACTGCTGGCCACGCAGACTCACCAAGCCACAG
ACTTGTCTTCCACAAGCACTTTCTTATCTTAGCCACAAAGTGACCAAGCCACATGTACTAAGGGTTGAAA
TCAAAGATATGTACAGGGTATTAAGCAAATCTGGTTATATGTTTTAAAACAACTTCTAAGACAAATTGAT
GGCAAGTTTGTGTGAAAGTTTTATATCAAAGTTGTTATAAGAGGTTCCTGAGCAAACCAATTGAAATACA
GTCATGCATTGCTTAATGACAGGGATATGTTCTGAAAGGATGCATCATTAGGCCATTGTGTCATTGTGCA
TGCATCATAGCATGTACTTACACAAACCTACATGGTACGGCCTACTATGCGCCTAGGCTATATGGTATGG
CCCATTGTTCCTAGGCTATAAACCTTTACAGCATATTACTGTACTGAACACTGTAGGCAGTTGTAACAAG
TGGTAAGCATTTGTATATGTAAACATAGAAAAGGTACAATAAAAATTCAGTATTATAATCTTATGGGACC
ACCATCACATATGTGGTCTGTCATTGACCAAAATGTCATCATGCAGTGCATGACTATATTTCTGTCTCAG
TAGGGGCATTCATAGGGGAAAAACGGAGTCTAGTTTCAAGATGATTAGGCTGGGCAGTCACTTGGGATTG
TAACCTTCATTCCTCAGAAGGAAGGGGTTCTTGATCTCATTGAGATCTACCAGAAAATTGCTGAAGCCAT
TTATCAAGAATGCAACTTACTTCCTAGATAGGATTACTCATCACATCAGACCCAAAATTTTGCCCAGCTC
AGGTTTGGTTCCTCTCCTCATTCCTGGTTGATAATAATCTAGTATGTATACATAATTTAAATGTTATTCT
CCATGAAAAACCAAAGTTTTGTTTTTAATAAAGAAAAATGTCTATCCAAATATAATTTTCAAAAATCTGA
AAAGATGACTCATACAAATATAGAATGAATAAAGCTTTTATTTAATTCATTAATTAAGGAACCAGTAAGA
TGGTAAAGCTGGTTCAAAGGAAAATTCAAGGAATGGAAATGTGTATATCAGTCAGTCCAGTGATTGTTGA
AATGAATTTCCTAATAGATGCAAAACTGGGTAATGTCCTATAGGGCAAAACATTGTAATCTTTGAGGTGA
TCTTTTAAATAGCAAAGTCAAACGGTGGTACATTCTCCAGCTAATTAAAGAATAATTGAGTGAGCCTATT
AAACAGTACCCTAGTATAATTTGGAAAGGCTGCATCTCCATCTTGCCTTATTTTTAGGTTTGAGATAATT
TTTCTTTACATGGTCATTGCTAAGTGTGCAATGAGATGATACTGTACTGGAAGGAACATACATTGGTATA
GTATTTCTGGAAAGCAGTTTGGCAGTGTGTGTTAAGAACTTAAAAGTTTAATTTTTAGGCCAGGTGCTGT
GGCTCATGCCTGTAATCCCAGCATTTTGGGGGTCCAAAGCGGGCGGATCACTTGAGGTCAGGAGTTTGAG
ACCAGCCTGATGGTGAAACCCCATCTCCACTAAAAATACAAAATTTAGCCAGGTGTGGTGGCGCATGTCT
GTAATCCCAGCTACTCAGGAGGCTGAGGCACGAGAATTACTTGAACCCAGGAGGCGGAGATTGCAGTGAG
CCGAGATCACAACACTGCACTCCAGCCTGGGCGACAGACCAAGACTCTCTCTCAAAAAACAAAACAAAAC
TTAAAACTCTAATTTTTATACCCTTTGATCCAGTAATTTCACTTGTAAGACTTTATTCCAAAGAAATAAT
CAAAAGATGCAATCAAAGATTTGTGTGAAGTGTATAATTATGCAATAAGTGTTTTGAGCACACTATGCAG
ATGGTCACCACAGTTTTCTTTTTATTACAAAAAGTTGGGAACACTTCAAATTCCAATAATAGAGGATAAA
TTATGGCGTCCTCTTAAATATGATGTGGCCCCATTACAAATGGATTTTTGAAAGTTTTTTTTTTTTCCTT
TTTTTTTTGTGGTGGAGTTTCACTTTGTCACCCAGGCTGGAGTGCAATGGTGCGATCTCAGCTCACCGCA
ACCTCTGCCTCCCGGGTTCCAGTGATTCTCCAGCCTCAGCCTCCTGAGTAGCTGGGATTGCAGGTGCCCG
CTACCATGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCATCATGTTGGGCAGGCTGGTCTT
GAACTCCTGAGCTCAGGTGATCTGCCCACCTGGGCCTCCTGAAGTGCTGGGATTACAGGCGTGAACTGCC
ATGCTTGGCCGTATTTTTTAAAGTTCTTAATGAGGGAAGTCAAGATGTAAAACCATATATTTATTATTAT
CTCCATTATATACACACATACATGTATACAGAGAGAAAAAGTAATGAAAATAACCAAAATATTAACAATA
AGTATCTGTGTTATAGAATTATGATTGTTTTTTCCCGTTTTCCAAATTTTCTACAGTAAAACTTTTGAAG
CTTTTATAACCAGGAAAAAAATTTAAAAGTTTGCAATGCATTCCAGAAATAAGTGTCTCAAACTTTGCTA
ATTTGAATTGTTCATGCCTTCTCTGCCTGCCTTCTCCACCTTCCTCCCTGGGGCTGGTGTTCCCGGCTTG
ACATTTTAAACCCTGTAAGTGGAGAGCAGTGGAAGAATGATGCCCCAGCCCTGAGAGCTGAGGGCGGCCC
TGTTTGTATTTTCTTAGGTTGCTGTAGATGTCACAGGGAGTTCCGGGCCATCACAGCCAGGGAACACAGG
ATGTTGCCAGGTGTGGGAAAAGGCCTTTAGGGTGGTCAGAGTCCCGAAGGGAGCCTCCTAATTCCCAGTT
GGGGAATGGAGATTTCAAGCGAGTTCTTGTTTCCAGGCTGAGATGAGCACACTTGCCTCTTACCCACTGG
CCCAGTGGATCCTAACCTTGGCTACAAATGAGAATCACCCGGGGGACCTTTAAACAAACACTGTTGCCAC
TATCCCACCCACAGTCAATCAAATCAGACTTTGTAGGGGTGGTCCCGGCATCAGTGGTTTTTCAGAAGTT
CCTCAACTGATTTAAATGCACAATGGAAGTTGACAACCACCAGACTGAAGATACCACGTGTGTTAATGGG
CCCAATGTATTCAAGGCCCAGTAGTTGGCCCCATCTCCCCTGGTATCCTAAGAACTCTAAATCCTTTCTA
GCTATTCGCTTGTCAAACTCCTGAGCTTACTTTCAATGGAGCTTACACATTCCCTCCTTCCCTCACATGA
CCCCAGGCACAGTTAATGGTTGTTCCTAGAGGACTTTGTCTTTGTTCCTTGGGGATCAGGTGGAGTGAGA
CAGTATCCCCAAGACTAAGATCTCTGAGGAGAGTAAAGACACCATCTCTGTGCCTCTGGTTCCTGCTACA
GAGTAACTTCCTGATGGTTGCCAAAAGAATGAACAGAAGAATGAATGAATGCAGCGGTTCTTCCTGCCAT
CTGATAACAGACTATTCTTTGATGTTTTCATTTTCAGGATGTACAGATTATAGTGTTTCCAGAAGATGGC
ATTCATGGATTCAACTTTACAAGAACATCCATTTATCCATTTTTGGACTTCATGCCGTCTCCCCAGGTGG
TCAGGTGGAACCCATGCCTGGAGCCTCACCGCTTCAATGACACAGAGGTGATTCCTGCCTTTTTCCTCAG
TAGGCTGAGGGTACACAGAGGTGATCTAAGTCAGGGACCAGAAGCTGTGACATGTTAACTAAGATTGATA
GGAGACCTTAACATCCCCAAAATCCAACCCAAACTCCCAAAGATCCATGTGCCACATGTTCATTCCATTA
AAGAATGTCTGACGTTACAAGGCAGTTATTCATCTATGGATCTTTCCATTTATTAATTACACAATAAATA
CAGGAATGTATACTTAAACCAAACCAAAAGTAAAAAAAGAAAAGTTCATCTTCACCACAGCCTGCACCTC
ATCCCATGCCCTTGCTTAGAGAAACTGCCATCAACAATTTGATGTGCATTCAGTTGTATTCTTTTCTATG
CATTTCATAGTTATTGACATCCTCTTTTTTTTTTTTTTTTTTGAGATGGAGTCTTACTCTGCCACCCAGG
CTGGAGCGCAGTGGCGCGATCTCAGCTCACTGCAAGCTCTGCCTTCCGGGTTCATGCCATTCTCCTGCCT
CAGCCTCCCGAGTAGCTGGGACTACAGGCACCCACCACCACGCCCGGCTAATTTTTTTTGTGTGTGTATT
TTTAGTAGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCTAC
CTCGGCCTGCCAAAGTGCTGGGATTACAGGCATGAGCCACTGTGCCTGGCCTTGACATCCTCTTTTTAAG
CATACTATATGCTTATTCATTTTAAATTTTTGCTATTATATTTTTGTAAACATGTTCAAGTTTTTCTGTA
AAATAAAATTTTTAGAAATGAAATCCCTCAGGCCAGGTGTGGTGGCTCACACCTGTAATCCCAGCTACTT
GGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGCAGGAGTTGCGGTGAGAAAGATCGCGCCACTG
CATTCCAGCCTGGACAACAGGAGCAAAACTCTGCCTCAAAAAAAAAAAAAAAAATAAAATAAAATAAAGA
AATGGAATCCCTCAAAGGATATGTACATTTTAAATTATATTAAAGAGTACCAAATTTCCCGCTTAAAAAA
CTTTGATTTCACTTTACAGCCCCAGTCATACAGTATGAGTGCCTCTTTTTCCATCCTTTGGTCAATGCAA
GATAGAATAATCTTTTGAGCCTGGGCACAGTGCTTCACATCTGTAATCCCAGCATTCTGGGAGGCCAAGG
CTGGTGGATAGCTTGAGCTCATGAGTTCAAGACCAGCCTGGCCAACATGGTGAAACCTCGTCTCTACAAT
AAATACAAAAATTAGCTGGGTGTGGTGGTGCATGCCTGTAGTCCCAGCCACTCAGAAGGCTGAGATAGGA
GGATGGCTTGAGCCTGGGAGGCGGAAGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGGGCG
ACAGAGCCAGACCCTGCCTCAAAAAAAAAAGAAAAAGAAGAATCTTTTGAATTTTTGCCAGTCTTATGAA
GGTGAGAAATGATAGCTATTTCATTGTTGTAATTTGCACTTCTCTCTCACTAATGAGATTGAGCATCTTT
TGAGATGTTTGTGGGTCACTTTTCTTTGTCCTTCTGTGAATCACCTGTTTATATCCTTTGCACATTTTCA
GTAGTGGTTGCTTTTTTCTTATTGATTTATGATAGCTGTTTATTATGGATAAATATAAGTACTTTTATAT
TTAAAAATTGTGAGAGCCAAGTACAATGGTGCACACCTGTAGTCCCAGCTTCTTAGGAGGCTGAGACGAG
AGGATTGCTTGAGGCCAGGAGTTTGAGTCCAGCCTGGGCAATGTAACAAGACCCTGTCTCTGAAAAAAAA
AAAAAAGAAAAGAAAGAAAAAAAAAAGAAGAGGAAGCAAAAGGAAGGATTTTAAAAACTCATTTATTTAA
TTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTATTTTGAGACGGAGTCTTGCTCTGTCG
CCCAGGCTGGAGTGCAGTGGCGCGATCTCGGCTCACTGCAAGCTCCGCCTACTGGGTTCACGCCATTCTC
CTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCATCCACCACCACGCCCGGCTAATTTTTTGTATTTT
TAGTTGAGATGGGGTTTCACCGTGTTAGCCAGGGTGGTCTCAATCTCCTGACCTCATGATCCACCCGCCT
CAGCCTCCCACAGTGCTGGGATTACAGGCAAAAACCTCATTTATTTACACCTTTTTTTCCTCTAGGTGCT
CCAGCGCCTGAGTTGTATGGCCATCAGGGGAGATATGTTCTTGGTGGCCAATCTTGGGACAAAGGAGCCT
TGTCATAGCAGTGACCCAAGGTGCCCAAAAGATGGGAGATACCAGTTCAACACAAATGTCGTGTTCAGCA
ATAATGGAACCCTTGTTGACCGCTACCGTAAACACAACCTCTACTTTGAGGCAGCATTCGATGTTCCTCT
TAAAGTGGATCTCATCACCTTTGATACCCCCTTTGCTGGCAGGTTTGGCATCTTCACATGCTTTGATATA
TTGTTCTTTGACCCTGCCATCAGAGTCCTCAGAGACTACAAGGTGAAGCATGTTGTGTACCCAACTGCCT
GGATGAACCAGCTCCCACTCTTGGCAGCAATTGAGATTCAGAAAGCTTTTGCTGTTGCCTTTGGCATCAA
CGTTCTGGCAGCTAATGTCCACCACCCAGTTCTGGGGATGACAGGAAGTGGCATACACACCCCTCTGGAG
TCCTTTTGGTACCATGACATGGAAAATCCCAAAAGTCACCTTATAATTGCCCAGGTGGCCAAAAATCCAG
TGGGTCTCATTGGTGCAGAGAATGCAACAGGTGAAACGGACCCATCCCATAGTAAGTTTTTAAAAATTTT
GTCAGGCGATCCGTACTGTGAGAAGGATGCTCAGGAAGTCCACTGTGATGAGGCCACCAAGTGGAACGTG
AATGCTCCTCCCACATTTCACTCTGAGATGATGTATGACAATTTCACCCTGGTCCCTGTCTGGGGAAAGG
AAGGCTATCTCCACGTCTGTTCCAATGGCCTCTGCTGTTATTTACTTTACGAGAGGCCCACCTTATCCAA
AGAGCTGTATGCCCTGGGGGTCTTTGATGGGCTTCACACAGTACATGGCACTTACTACATCCAAGTGTGT
GCCCTGGTCAGGTGTGGGGGTCTTGGCTTCGACACCTGTGGACAGGAAATCACAGAGGCCACGGGGATAT
TTGAGTTTCACCTGTGGGGCAACTTCAGTACTTCCTATATCTTTCCTTTGTTTCTGACCTCAGGGATGAC
CCTAGAAGTCCCTGACCAGCTTGGCTGGGAGAATGACCACTATTTCCTGAGGAAAAGTAGGCTGTCCTCT
GGGCTGGTGACGGCGGCTCTCTATGGGCGCTTGTATGAGAGGGACTAGGAAAAGTGTGTGGTCTGTGGGG
CGGACTCTGGCCATCATGTTGACAGCCTTGCACTTCCACAGGCTACAAGCCCTGGGACCATCTTTCTGCC
TTAAGGGCAGGAGCCCACTTCTGTGGCACCAGATTCCACCCTGGGAACTGTGGAAAAAGTAGGAGAGGCA
GATTCCCTCAGTGTCTTCCTCTTAAACCTCAATCATCGAGACATTAGGGGGTATTTTCTGTTCACATTTA
TCTTTTTCAAGCCACATCTTCCTCTAACAAATCTCTCAGTATGCGATTGGTCTCAAGCTAAAACAAAAAT
AAATGTCAGTTTATATTTTACACATCCACAAA
Pfam (2 motifs)
|
Pfam |
Position(Independent E-value) |
Description |
|
Vanin_C |
394..543(7.3e-31) |
PF19018, Vanin C-terminal domain |
|
CN_hydrolase |
88..275(3.5e-14) |
PF00795, Carbon-nitrogen hydrolase |
Evolutionary analysis by Maximum Likelihood method
The evolutionary history was inferred by using the Maximum Likelihood method and JTT matrix-based model [1]. The tree with the highest log likelihood (-1343.01) is shown. Initial tree(s) for the heuristic search were obtained automatically by applying Neighbor-Join and BioNJ algorithms to a matrix of pairwise distances estimated using a JTT model, and then selecting the topology with superior log likelihood value. The proportion of sites where at least 1 unambiguous base is present in at least 1 sequence for each descendent clade is shown next to each internal node in the tree. This analysis involved 100 amino acid sequences. There were a total of 148 positions in the final dataset.
|
SNP |
COORDINATE |
AMINO ACID CHANGE |
GENE ID |
TRANSCRIPT ID |
PROTEIN ID |
SIFT SCORE |
SIFT MEDIAN |
SIFT PREDICTION |
|
rs397507170 |
15677070 |
V62L |
ENSG00000169814 |
ENST00000303498 |
ENSP00000306477 |
0.004 |
2.51 |
DELETERIOUS |
|
rs397507170 |
15677070 |
V42L |
ENSG00000169814 |
ENST00000383778 |
ENSP00000373288 |
0.004 |
2.5 |
DELETERIOUS |
|
rs397507170 |
15677070 |
V64L |
ENSG00000169814 |
ENST00000437172 |
ENSP00000400995 |
0.004 |
2.5 |
DELETERIOUS |
|
rs397507170 |
15677070 |
V64L |
ENSG00000169814 |
ENST00000449107 |
ENSP00000388212 |
0.004 |
2.56 |
DELETERIOUS |
|
rs397507171 |
15677131 |
A82D |
ENSG00000169814 |
ENST00000303498 |
ENSP00000306477 |
0 |
2.64 |
DELETERIOUS |
|
rs397507171 |
15677131 |
A62D |
ENSG00000169814 |
ENST00000383778 |
ENSP00000373288 |
0 |
2.61 |
DELETERIOUS |
|
rs397507171 |
15677131 |
A84D |
ENSG00000169814 |
ENST00000437172 |
ENSP00000400995 |
0 |
2.64 |
DELETERIOUS |
|
rs397507171 |
15677131 |
A84D |
ENSG00000169814 |
ENST00000449107 |
ENSP00000388212 |
0 |
2.7 |
DELETERIOUS |
|
rs397507171 |
15677131 |
A82V |
ENSG00000169814 |
ENST00000303498 |
ENSP00000306477 |
0 |
2.64 |
DELETERIOUS |
|
rs397507171 |
15677131 |
A62V |
ENSG00000169814 |
ENST00000383778 |
ENSP00000373288 |
0 |
2.61 |
DELETERIOUS |
|
rs397507171 |
15677131 |
A84V |
ENSG00000169814 |
ENST00000437172 |
ENSP00000400995 |
0 |
2.64 |
DELETERIOUS |
|
rs397507171 |
15677131 |
A84V |
ENSG00000169814 |
ENST00000449107 |
ENSP00000388212 |
0 |
2.7 |
DELETERIOUS |
|
rs397507172 |
15683431 |
V109G |
ENSG00000169814 |
ENST00000303498 |
ENSP00000306477 |
0 |
2.52 |
DELETERIOUS |
|
rs397507172 |
15683431 |
V89G |
ENSG00000169814 |
ENST00000383778 |
ENSP00000373288 |
0 |
2.5 |
DELETERIOUS |
|
rs397507172 |
15683431 |
V111G |
ENSG00000169814 |
ENST00000437172 |
ENSP00000400995 |
0 |
2.51 |
DELETERIOUS |
|
rs397507172 |
15683431 |
V111G |
ENSG00000169814 |
ENST00000449107 |
ENSP00000388212 |
0 |
2.56 |
DELETERIOUS |
|
rs397507173 |
15685922 |
P187S |
ENSG00000169814 |
ENST00000303498 |
ENSP00000306477 |
0.078 |
2.51 |
TOLERATED |
|
rs397507173 |
15685922 |
P189S |
ENSG00000169814 |
ENST00000437172 |
ENSP00000400995 |
0.078 |
2.51 |
TOLERATED |
|
rs397507173 |
15685922 |
P167S |
ENSG00000169814 |
ENST00000383778 |
ENSP00000373288 |
0.087 |
2.5 |
TOLERATED |
|
rs397507173 |
15685922 |
P189S |
ENSG00000169814 |
ENST00000449107 |
ENSP00000388212 |
0.087 |
2.56 |
TOLERATED |
Evolutionary analysis of coding SNPs
|
SNP |
Substitution |
Probability of deleterious effect |
Pdel |
|
rs13073139 |
A171T |
probably damaging |
0.78 |
|
rs13078881 |
D444H |
probably damaging |
0.85 |
|
rs28934601 |
D252G |
probably benign |
0.27 |
|
rs34885143 |
G45R |
probably benign |
0.13 |
|
rs35034250 |
P391S |
possibly damaging |
0.5 |
|
rs35145938 |
Y428Y |
probably damaging |
0.86 |
|
rs80338685 |
Q456H |
probably damaging |
0.85 |
|
rs80338686 |
R538C |
probably damaging |
0.85 |
|
rs104893687 |
R79C |
probably damaging |
0.78 |
|
rs104893688 |
T532M |
probably damaging |
0.57 |
|
rs138818907 |
P497S |
probably damaging |
0.86 |
|
rs146015592 |
R157H |
probably damaging |
0.57 |
|
rs146136265 |
D543E |
probably damaging |
0.85 |
|
rs146600671 |
V457M |
probably benign |
0.19 |
|
rs151071780 |
Q88E |
probably benign |
0.27 |
|
rs181396238 |
A478T |
probably damaging |
0.78 |
|
rs190386869 |
L215V |
probably damaging |
0.85 |
|
rs200337373 |
D222N |
probably damaging |
0.57 |
|
rs372687866 |
Y261Y |
probably benign |
0.19 |
|
rs372844636 |
R211C |
possibly damaging |
0.5 |
|
rs372844636 |
R191C |
probably damaging |
0.85 |
|
rs374681173 |
T152A |
probably damaging |
0.85 |
|
rs375712490 |
G114V |
probably damaging |
0.86 |
|
rs397507170 |
V62M |
probably damaging |
0.85 |
|
rs397507170 |
V62L |
probably damaging |
0.85 |
|
rs397507171 |
A82D |
probably damaging |
0.85 |
|
rs397507171 |
A82V |
probably damaging |
0.85 |
|
rs397507172 |
V109G |
probably damaging |
0.85 |
|
rs397507173 |
P187S |
probably damaging |
0.86 |
Provean
|
SNP Id’s |
Amino Acid Change |
Probability |
Prediction |
Score |
|
rs13073139 |
A171T |
Deleterious |
Damaging |
-3.72 |
|
rs13073139 |
A151T |
Deleterious |
Damaging |
-3.72 |
|
rs13073139 |
A173T |
Deleterious |
Damaging |
-3.72 |
|
rs13073139 |
A173T |
Deleterious |
Damaging |
-3.72 |
|
rs13078881 |
D444H |
Deleterious |
Damaging |
-5.48 |
|
rs13078881 |
D446H |
Deleterious |
Damaging |
-5.48 |
|
rs13078881 |
D446H |
Deleterious |
Damaging |
-5.48 |
|
rs13078881 |
D424H |
Deleterious |
Damaging |
-5.48 |
|
rs28934601 |
D252G |
Deleterious |
Damaging |
-4.8 |
|
rs28934601 |
D254G |
Deleterious |
Damaging |
-4.8 |
|
rs28934601 |
D254G |
Deleterious |
Damaging |
-4.8 |
|
rs34885143 |
G47R |
Neutral |
Tolerated |
-0.39 |
|
rs34885143 |
G25R |
Neutral |
Tolerated |
-0.32 |
|
rs34885143 |
G45R |
Neutral |
Tolerated |
-0.35 |
|
rs34885143 |
G47R |
Neutral |
Tolerated |
-0.09 |
|
rs35034250 |
P393S |
Neutral |
Tolerated |
-0.63 |
|
rs35034250 |
P391S |
Neutral |
Tolerated |
-0.63 |
|
rs35034250 |
P393S |
Neutral |
Tolerated |
-0.63 |
|
rs35034250 |
P371S |
Neutral |
Tolerated |
-0.63 |
|
rs35145938 |
Y428Y |
Neutral |
Tolerated |
0 |
|
rs35145938 |
Y408Y |
Neutral |
Tolerated |
0 |
|
rs35145938 |
Y430Y |
Neutral |
Tolerated |
0 |
|
rs35145938 |
Y430Y |
Neutral |
Tolerated |
0 |
|
rs80338685 |
Q456H |
Deleterious |
Damaging |
-4.55 |
|
rs80338685 |
Q436H |
Deleterious |
Damaging |
-4.55 |
|
rs80338685 |
Q458H |
Deleterious |
Damaging |
-4.55 |
|
rs80338685 |
Q458H |
Deleterious |
Damaging |
-4.55 |
|
rs80338686 |
R538C |
Deleterious |
Damaging |
-7.75 |
|
rs80338686 |
R518C |
Deleterious |
Damaging |
-7.75 |
|
rs80338686 |
R540C |
Deleterious |
Damaging |
-7.75 |
|
rs80338686 |
R540C |
Deleterious |
Damaging |
-7.75 |
|
rs104893687 |
R79C |
Deleterious |
Damaging |
-5.21 |
|
rs104893687 |
R81C |
Deleterious |
Damaging |
-5.22 |
|
rs104893687 |
R59C |
Deleterious |
Damaging |
-5.21 |
|
rs104893688 |
T532M |
Deleterious |
Damaging |
-4.11 |
|
rs104893688 |
T534M |
Deleterious |
Damaging |
-4.11 |
|
rs104893688 |
T534M |
Deleterious |
Damaging |
-4.11 |
|
rs104893688 |
T512M |
Deleterious |
Damaging |
-4.11 |
|
rs138818907 |
P497S |
Deleterious |
Damaging |
-7.77 |
|
rs138818907 |
P477S |
Deleterious |
Damaging |
-7.77 |
|
rs138818907 |
P499S |
Deleterious |
Damaging |
-7.77 |
|
rs138818907 |
P499S |
Deleterious |
Damaging |
-7.77 |
|
rs146015592 |
R157H |
Deleterious |
Damaging |
-3.7 |
|
rs146015592 |
R159H |
Deleterious |
Damaging |
-3.7 |
|
rs146015592 |
R137H |
Deleterious |
Damaging |
-3.7 |
|
rs146015592 |
R159H |
Deleterious |
Damaging |
-3.7 |
|
rs146136265 |
D543E |
Deleterious |
Damaging |
-3.65 |
|
rs146136265 |
D523E |
Deleterious |
Damaging |
-3.65 |
|
rs146136265 |
D545E |
Deleterious |
Damaging |
-3.65 |
|
rs146136265 |
D545E |
Deleterious |
Damaging |
-3.65 |
|
rs146600671 |
V459M |
Neutral |
Damaging |
-2.34 |
|
rs146600671 |
V457M |
Neutral |
Damaging |
-2.34 |
|
rs146600671 |
V459M |
Neutral |
Damaging |
-2.34 |
|
rs146600671 |
V437M |
Neutral |
Damaging |
-2.34 |
|
rs151071780 |
Q90E |
Neutral |
Tolerated |
-0.85 |
|
rs151071780 |
Q68E |
Neutral |
Tolerated |
-0.85 |
|
rs151071780 |
Q88E |
Neutral |
Tolerated |
-0.85 |
|
rs151071780 |
Q90E |
Neutral |
Tolerated |
-0.85 |
|
rs181396238 |
A478T |
Deleterious |
Damaging |
-3.55 |
|
rs181396238 |
A480T |
Deleterious |
Damaging |
-3.55 |
|
rs181396238 |
A480T |
Deleterious |
Damaging |
-3.55 |
|
rs190386869 |
L195V |
Deleterious |
Damaging |
-2.73 |
|
rs190386869 |
L217V |
Deleterious |
Damaging |
-2.73 |
|
rs190386869 |
L215V |
Deleterious |
Damaging |
-2.73 |
|
rs190386869 |
L217V |
Deleterious |
Damaging |
-2.73 |
|
rs200337373 |
D202N |
Neutral |
Tolerated |
-1.9 |
|
rs200337373 |
D224N |
Neutral |
Tolerated |
-1.9 |
|
rs200337373 |
D222N |
Neutral |
Tolerated |
-1.9 |
|
rs200337373 |
D224N |
Neutral |
Tolerated |
-1.9 |
|
rs372687866 |
Y261Y |
Neutral |
Tolerated |
0 |
|
rs372687866 |
Y241Y |
Neutral |
Tolerated |
0 |
|
rs372687866 |
Y263Y |
Neutral |
Tolerated |
0 |
|
rs372687866 |
Y263Y |
Neutral |
Tolerated |
0 |
|
rs372844636 |
R211C |
Deleterious |
Damaging |
-4.14 |
|
rs372844636 |
R213C |
Deleterious |
Damaging |
-4.14 |
|
rs372844636 |
R213C |
Deleterious |
Damaging |
-4.14 |
|
rs372844636 |
R191C |
Deleterious |
Damaging |
-4.14 |
|
rs374681173 |
T154A |
Deleterious |
Tolerated |
-3.73 |
|
rs374681173 |
T154A |
Deleterious |
Tolerated |
-3.73 |
|
rs374681173 |
T152A |
Deleterious |
Tolerated |
-3.73 |
|
rs374681173 |
T132A |
Deleterious |
Tolerated |
-3.73 |
|
rs375712490 |
G114V |
Deleterious |
Damaging |
-6.94 |
|
rs375712490 |
G116V |
Deleterious |
Damaging |
-6.94 |
|
rs375712490 |
G116V |
Deleterious |
Damaging |
-6.94 |
|
rs375712490 |
G94V |
Deleterious |
Damaging |
-6.94 |
|
rs397507170 |
V62M |
Deleterious |
Damaging |
-2.71 |
|
rs397507170 |
V42M |
Deleterious |
Damaging |
-2.71 |
|
rs397507170 |
V64M |
Deleterious |
Damaging |
-2.71 |
|
rs397507170 |
V64M |
Deleterious |
Damaging |
-2.71 |
SNAP 2
|
Wildtype amino acid |
Position |
Variant Amnio Acid |
Predicted Effect |
Score |
Expected Accuracy |
|
A |
171 |
T |
Effect |
89 |
95% |
|
A |
151 |
T |
Effect |
56 |
95% |
|
A |
173 |
T |
Effect |
76 |
87% |
|
A |
173 |
T |
Effect |
34 |
80% |
|
D |
444 |
H |
Effect |
67 |
65% |
|
D |
46 |
H |
Effect |
87 |
75% |
|
D |
446 |
H |
Effect |
45 |
90% |
|
D |
424 |
H |
Neutral |
34 |
95% |
|
D |
252 |
G |
Effect |
76 |
45% |
|
D |
254 |
G |
Effect |
56 |
35% |
|
D |
254 |
G |
Effect |
45 |
70% |
|
G |
47 |
R |
Effect |
98 |
70% |
|
G |
25 |
R |
Effect |
23 |
87% |
|
G |
45 |
R |
Neutral |
-25 |
80% |
|
P |
47 |
R |
Neutral |
78 |
65% |
|
P |
393 |
S |
Neutral |
65 |
75% |
|
P |
391 |
S |
Effect |
45 |
90% |
|
P |
393 |
S |
Effect |
67 |
95% |
|
P |
371 |
S |
Effect |
87 |
45% |
|
Y |
428 |
Y |
Effect |
90 |
35% |
|
Y |
408 |
Y |
Effect |
56 |
89% |
|
Y |
430 |
Y |
Effect |
87 |
90% |
|
Y |
430 |
Y |
Effect |
56 |
95% |
|
Q |
458 |
H |
Effect |
34 |
45% |
|
Q |
430 |
H |
Neutral |
56 |
35% |
|
Q |
458 |
H |
Neutral |
78 |
70% |
|
Q |
538 |
H |
Effect |
45 |
70% |
|
R |
518 |
C |
Effect |
54 |
87% |
|
R |
540 |
C |
Effect |
78 |
90% |
|
R |
540 |
C |
Effect |
65 |
95% |
|
R |
79 |
C |
Effect |
98 |
45% |
|
R |
81 |
C |
Effect |
56 |
35% |
|
R |
59 |
C |
Effect |
45 |
70% |
|
T |
532 |
M |
Effect |
76 |
70% |
|
T |
534 |
M |
Effect |
36 |
87% |
|
T |
534 |
M |
Effect |
76 |
90% |
|
T |
512 |
M |
Neutral |
56 |
54% |
Polyphen 2
|
Rs_Id |
Mutation Probability |
Score |
|
rs13073139 |
Probably damaging |
0.98 |
|
rs13073139 |
Possibly damaging |
0.98 |
|
rs13073139 |
Possibly damaging |
1.00 |
|
rs13073139 |
Probably damaging |
0.999 |
|
rs13078881 |
Probably damaging |
0.98 |
|
rs13078881 |
Possibly damaging |
0.98 |
|
rs13078881 |
Possibly damaging |
1.00 |
|
rs13078881 |
Probably damaging |
0.999 |
|
rs28934601 |
Possibly damaging |
1.00 |
|
rs28934601 |
Probably damaging |
0.98 |
|
rs28934601 |
Possibly damaging |
1.00 |
|
rs34885143 |
Probably damaging |
0.999 |
|
rs34885143 |
Probably damaging |
0.98 |
|
rs34885143 |
Possibly damaging |
0.98 |
|
rs34885143 |
Possibly damaging |
1.00 |
|
rs35034250 |
Probably damaging |
0.999 |
|
rs35034250 |
Probably damaging |
0.999 |
|
rs35034250 |
Possibly damaging |
1.00 |
|
rs35034250 |
Probably damaging |
0.98 |
|
rs35145938 |
Possibly damaging |
0.98 |
|
rs35145938 |
Possibly damaging |
1.00 |
|
rs35145938 |
Possibly damaging |
1.00 |
|
rs35145938 |
Probably damaging |
0.98 |
|
rs80338685 |
Possibly damaging |
1.00 |
|
rs80338685 |
Probably damaging |
0.999 |
|
rs80338685 |
Possibly damaging |
1.00 |
|
rs80338685 |
Probably damaging |
0.98 |
|
rs80338686 |
Probably damaging |
0.98 |
|
rs80338686 |
Possibly damaging |
0.98 |
|
rs80338686 |
Possibly damaging |
1.00 |
|
rs80338686 |
Possibly damaging |
0.999 |
|
rs104893687 |
Possibly damaging |
1.00 |
|
rs104893687 |
Probably damaging |
0.999 |
|
rs104893687 |
Probably damaging |
0.999 |
|
rs104893688 |
Probably damaging |
0.98 |
|
rs104893688 |
Possibly damaging |
0.98 |
|
rs104893688 |
Possibly damaging |
1.00 |
|
rs104893688 |
Possibly damaging |
1.00 |
|
rs138818907 |
Possibly damaging |
0.98 |
|
rs138818907 |
Possibly damaging |
1.00 |
|
rs138818907 |
Probably damaging |
0.999 |
|
rs138818907 |
Probably damaging |
0.98 |
|
rs146015592 |
Possibly damaging |
0.98 |
|
rs146015592 |
Probably damaging |
0.98 |
|
rs146015592 |
Possibly damaging |
0.98 |
|
rs146015592 |
Possibly damaging |
1.00 |
Hope Prediction
|
SNP Id’s |
Mutation |
Mapping issue |
AA |
Function. |
Score |
|
rs13073139 |
A171T |
|
A171T |
|
8.7 |
|
rs13073139 |
A151T |
Uniprot residue:A |
A151T |
|
|
|
rs13073139 |
A173T |
|
A173T |
|
6.45 |
|
rs13078881 |
D444H |
|
D444H |
|
6.99 |
|
rs13078881 |
D446H |
|
D446H |
|
5.77 |
|
rs13078881 |
D424H |
Uniprot residue:A |
D424H |
|
6.76 |
|
rs28934601 |
D252G |
|
D252G |
|
4.78 |
|
rs34885143 |
G47R |
|
G47R |
|
3.21 |
|
rs34885143 |
G25R |
Uniprot residue:A |
G25R |
|
8.34 |
|
rs34885143 |
G45R |
|
G45R |
|
1.00 |
|
rs35034250 |
P393S |
|
P393S |
|
2.00 |
|
rs35034250 |
P391S |
Uniprot residue:A |
P391S |
|
3.77 |
|
rs35034250 |
P371S |
|
P371S |
|
6.21 |
|
rs35145938 |
Y428Y |
|
Y428Y |
|
5.78 |
|
rs35145938 |
Y408Y |
|
Y408Y |
|
7.45 |
|
rs35145938 |
Y430Y |
Uniprot residue:A |
Y430Y |
|
9.07 |
|
rs80338685 |
Q456H |
|
Q456H |
|
1.06 |
|
rs80338685 |
Q436H |
|
Q436H |
|
3.00 |
|
rs80338685 |
Q458H |
|
Q458H |
|
4.76 |
|
rs80338686 |
R538C |
Uniprot residue:A |
R538C |
|
|
|
rs80338686 |
R518C |
|
R518C |
|
1.09 |
|
Rank |
C-Score |
Cluster Size |
PDB Hit |
Lig Name |
Consensus Building Residues |
|
1 |
0.50 |
26 |
112,212,216,218, 245,246,271,272, 273,308,399,450 |
||
|
2 |
0.04 |
3 |
113,172,173,174,195,221 |
||
|
3 |
0.02 |
2 |
118,119,120,217,218,219 |
||
|
4 |
0.02 |
2 |
87,154,157 |
||
|
5 |
0.01 |
1 |
N/A |
N/A |
243,248,250,254,258, 266,288,292,294,538 |
|
6 |
0.01 |
1 |
N/A |
N/A |
258,264,291,292,293, 353,356,374,494 |
|
7 |
0.01 |
1 |
271,272,273 |
||
|
8 |
0.01 |
1 |
283,285,309,312 |
||
|
9 |
0.01 |
1 |
216,249 |
||
|
10 |
0.01 |
1 |
358,359,361,362,363,364, 365,366,376,379,380,381, 382,516,517,518 |
|
Number of amino acids
|
543
|
Molecular weight
|
61132.92
|
Theoretical pI
|
5.81
|
Amino acid composition
|
Ala (A) 41 7.6%
Arg (R) 23 4.2%
Asn (N) 24 4.4%
Asp (D) 27 5.0%
Cys (C) 16 2.9%
Gln (Q) 17 3.1%
Glu (E) 31 5.7%
Gly (G) 38 7.0%
His (H) 24 4.4%
Ile (I) 26 4.8%
Leu (L) 54 9.9%
Lys (K) 19 3.5%
Met (M) 13 2.4%
Phe (F) 34 6.3%
Pro (P) 28 5.2%
Ser (S) 28 5.2%
Thr (T) 29 5.3%
Trp (W) 7 1.3%
Tyr (Y) 24 4.4%
Val (V) 40 7.4%
Pyl (O) 0 0.0%
Sec (U) 0 0.0%
|
Total number of negatively charged residues (Asp + Glu)
|
58
|
Total number of positively charged residues (Arg + Lys)
|
42 |
Formula
|
C2771H4193N727O782S29
|
Total number of atoms(12269)
|
8502
|
Instability index(II)
|
31.95
|
Stability
|
stable
|
Aliphatic index(AI)
|
86.37
|
GRAVY
|
-0.032
|
|
Alpha helix (Hh) : 117 is 21.55% 310 helix (Gg) : 0 is 0.00% Pi helix (Ii) : 0 is 0.00% Beta bridge (Bb) : 0 is 0.00% Extended strand (Ee) : 120 is 22.10% Beta turn (Tt) : 0 is 0.00% Bend region (Ss) : 0 is 0.00% Random coil (Cc) : 306 is 56.35% Ambiguous states (?) : 0 is 0.00% Other states : 0 is 0.00% |
Secondary Structure Prediction
Amino Acid Type
|
Name of enzyme |
No. of cleavages |
|
Arg-C proteinase |
23 |
|
Asp-N endopeptidase |
27 |
|
Asp-N endopeptidase + N-terminal Glu |
58 |
|
BNPS-Skatole |
7 |
|
CNBr |
13 |
|
Caspase1 |
1 |
|
Chymotrypsin-high specificity (C-term to [FYW], not before P) |
60 |
|
Chymotrypsin-low specificity (C-term to [FYWML], not before P) |
145 |
|
Clostripain |
23 |
|
Formic acid |
27 |
|
Glutamyl endopeptidase |
31 |
|
Iodosobenzoic acid |
7 |
|
Hydroxylamine |
2 |
|
LysC |
19 |
|
LysN |
19 |
|
NTCB (2-nitro-5-thiocyanobenzoic acid) |
16 |
|
Pepsin (pH1.3) |
122 |
|
Pepsin (pH>2) |
157 |
|
Proline-endopeptidase |
3 |
|
Proteinase K |
286 |
|
Staphylococcal peptidase I |
30 |
|
Thermolysin |
178 |
|
Trypsin |
41 |
|
Arg-C proteinase |
23 |
|
Rank |
Start position |
Sequence |
Score |
Prediction |
|
1 |
377 |
EVHCDEATKWNVNAPP |
0.95 |
Epitope |
|
2 |
310 |
GSGIHTPLESFWYHDM |
0.93 |
Epitope |
|
3 |
181 |
SSDPRCPKDGRYQFNT |
0.90 |
Epitope |
|
3 |
175 |
TKEPCHSSDPRCPKDG |
0.90 |
Epitope |
|
4 |
137 |
VVRWNPCLEPHRFNDT |
0.87 |
Epitope |
|
4 |
127 |
PFLDFMPSPQVVRWNP |
0.87 |
Epitope |
|
5 |
342 |
VGLIGAENATGETDPS |
0.86 |
Epitope |
|
6 |
410 |
GKEGYLHVCSNGLCCY |
0.84 |
Epitope |
|
6 |
3 |
HAHIQGGRRAKSRFVV |
0.84 |
Epitope |
|
7 |
513 |
GWENDHYFLRKSRLSS |
0.83 |
Epitope |
|
7 |
370 |
YCEKDAQEVHCDEATK |
0.83 |
Epitope |
|
7 |
105 |
VQIIVFPEDGIHGFNF |
0.83 |
Epitope |
|
8 |
434 |
SKELYALGVFDGLHTV |
0.82 |
Epitope |
|
8 |
385 |
KWNVNAPPTFHSEMMY |
0.82 |
Epitope |
|
8 |
260 |
DYKVKHVVYPTAWMNQ |
0.82 |
Epitope |
|
8 |
160 |
CMAIRGDMFLVANLGT |
0.82 |
Epitope |
|
9 |
528 |
SGLVTAALYGRLYERD |
0.81 |
Epitope |
|
10 |
39 |
ALGAHTGEESVADHHE |
0.80 |
Epitope |
|
11 |
52 |
HHEAEYYVAAVYEHPS |
0.79 |
Epitope |
|
11 |
349 |
NATGETDPSHSKFLKI |
0.79 |
Epitope |
|
11 |
281 |
AIEIQKAFAVAFGINV |
0.79 |
Epitope |
|
No of Nodes |
11 |
|
No of Edges |
18 |
|
Avg node degree |
3.27 |
|
avg. local clustering coefficient |
0.865 |
|
expected number of edges |
10 |
|
p-value |
0.0208 |
|
Protein – Protein Interaction network |
|
RNA Base Pairing Probability Plot
